SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells
| العنوان: | SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells |
|---|---|
| المؤلفون: | Jordana Muñoz-Basagoiti, Ferran Tarrés-Freixas, Benjamin Trinité, Martin Sachse, Sanjeev Gumber, Itziar Erkizia, Ester Ballana, Joaquim Segalés, Cristina Risco, Dàlia Raïch-Regué, Júlia Vergara-Alert, Maria Pino, Amalio Telenti, Nuria Izquierdo-Useros, Marc Elosua-Bayes, Jakub Chojnacki, Julià Blanco, Bonaventura Clotet, Victor Guallar, Roger Paredes, Jorge Carrillo, Mirko Paiardini, Ignacio Blanco, Daniel Perez-Zsolt, Holger Heyn, Xabier Muñiz-Trabudua, Marc Noguera-Julian, Javier Martinez-Picado, Eva Riveira-Muñoz, Jordi Rodon |
| المساهمون: | Grifols, YoMeCorono, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, William I. H. and Lula E. Pitts Foundation, Ministerio de Economía y Competitividad (España), Rodón, Jordi [0000-0002-1032-9091], Raïch-Regué, Dàlia [0000-0001-7656-5700], Risco, Cristina [0000-0001-7501-5934], Paiardini, Mirko [0000-0002-7276-3600], Ballana, Ester [0000-0002-5215-7363], Carrillo, Jorge [0000-0003-0221-5948], Heyn, Holger [0000-0002-3276-1889], Segalés, Joaquim [0000-0002-1539-7261], Martínez-Picado, Javier [0000-0002-4916-2129], Izquierdo-Useros, Núria [0000-0002-1039-1821], Rodón, Jordi, Raïch-Regué, Dàlia, Risco, Cristina, Paiardini, Mirko, Ballana, Ester, Carrillo, Jorge, Heyn, Holger, Segalés, Joaquim, Martínez-Picado, Javier, Izquierdo-Useros, Núria |
| المصدر: | Cellular and Molecular Immunology Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Springer Nature, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Sialic Acid Binding Ig-like Lectin 1, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Trans infection, Antigen-Presenting Cells, Biology, COVID-19 (Malaltia), Cell Line, Correspondence, Immunology and Allergy, Humans, skin and connective tissue diseases, SARS-CoV-2, fungi, SIGLEC, COVID-19, Dendritic Cells, respiratory system, Virology, N-Acetylneuraminic Acid, body regions, Infectious Diseases, Mechanisms of disease, Viral infection, Genètica, Receptors, Coronavirus |
| الوصف: | Antigen-presenting cells (APCs) may be resistant to SARS-CoV-2 infection but still contribute to viral pathogenesis. Lectins such as sialic acid-binding Ig-like lectin 1 (Siglec-1/CD169) mediate the attachment of viruses to APCs. Here, we show that APCs effectively capture SARS-CoV-2 within compartments via recognition of Siglec-1. This receptor interacts with sialylated gangliosides on membranes of SARS-CoV-2 variants, as previously shown for retroviruses or filoviruses [1]. Blockage of Siglec-1 on monocyte-derived dendritic cells (MDDCs) decreased SARS-CoV-2 viral transfer or trans-infection to bystander target cells. However, monocyte-derived macrophages (MDMs) capturing SARS-CoV-2 via Siglec-1 did not transmit infectious particles. The presence of pulmonary APCs co-expressing Siglec-1 and SARS-CoV-2 corroborated these findings in vivo. The research of the CBIG consortium (constituted by IRTA-CReSA, BSC, & IrsiCaixa) is supported by Grifols Pharmaceutical. The authors also acknowledge the crowdfunding initiative #Yomecorono (https://www.yomecorono.comTest). N.I.-U. is supported by the grant PID2020-117145RB-I00 from the Spanish Ministry of Science and Innovation. J.M.-P. is supported by the grant PID2019-109870RB-I00 from the Spanish Ministry of Science and Innovation and in part also by Grifols. The C.R. laboratory is funded by RTI2018-094445-B100 (MCIU/AEI/FEDER, UE). The NHP study was primarily supported by a YNPRC Coronavirus Pilot Research Project Program grant to M.Pa. under award P51 OD11132, Emergent Venture Fast grant program to M.Pa. under awards #2206 and #2144, and William and Lula Pitts Foundation (to M.Pa.). X.M.-T. is supported by the Spanish Ministry of Science and Innovation and the European Regional Development Fund under agreement BES-2017-082900. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2628ab3aaf6bca876e106abf2b081fTest http://hdl.handle.net/10230/52693Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7b2628ab3aaf6bca876e106abf2b081f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |