دورية أكاديمية
Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation
| العنوان: | Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation |
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| المؤلفون: | de Koning, Coco, Tao, Weiyang, Lacna, Amelia, van Veghel, Karin, Horwitz, Mitchell E., Sanz, Guillermo, Valcarcel Ferreiras, David |
| المساهمون: | Institut Català de la Salut, de Koning C University Medical Center Utrecht, Utrecht, The Netherlands. Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Tao W, Lacna A, van Veghel K University Medical Center Utrecht, Utrecht, The Netherlands. Horwitz ME Duke University Medical Center, Durham, NC, USA. Sanz G Hospital Universitario y Politécnico la Fe, València, Spain. Centro de Investigación Biomédica en Red de Cáncer, CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. Valcárcel D Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Trasplantació d'òrgans, teixits, etc, Sang fetal, Sang - Malalties - Tractament, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Cord Blood Stem Cell Transplantation, DISEASES::Neoplasms::Neoplasms by Site::Hematologic Neoplasms, Other subheadings::Other subheadings::/therapy, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre de la sangre del cordón, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias hematológicas, Otros calificadores::Otros calificadores::/terapia |
| الوصف: | Immunologia; Recerca mèdica ; Inmunología; Investigación médica ; Immunology; Medical research ; Omidubicel (nicotinamide-expanded cord blood) is a potential alternative source for allogeneic hematopoietic cell transplantation (HCT) when an HLA-identical donor is lacking. A phase I/II trial with standalone omidubicel HCT showed rapid and robust neutrophil and platelet engraftment. In this study, we evaluated the immune reconstitution (IR) of patients receiving omidubicel grafts during the first 6 months post-transplant, as IR is critical for favorable outcomes of the procedure. Data was collected from the omidubicel phase I-II international, multicenter trial. The primary endpoint was the probability of achieving adequate CD4+ T-cell IR (CD4IR: > 50 × 106/L within 100 days). Secondary endpoints were the recovery of T-cells, natural killer (NK)-cells, B-cells, dendritic cells (DC), and monocytes as determined with multicolor flow cytometry. LOESS-regression curves and cumulative incidence plots were used for data description. Thirty-six omidubicel recipients (median 44; 13–63 years) were included, and IR data was available from 28 recipients. Of these patients, 90% achieved adequate CD4IR. Overall, IR was complete and consisted of T-cell, monocyte, DC, and notably fast NK- and B-cell reconstitution, compared to conventional grafts. Our data show that transplantation of adolescent and adult patients with omidubicel results in full and broad IR, which is comparable with IR after HCT with conventional graft sources. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1476-5365 34312498 |
| العلاقة: | Bone Marrow Transplantation;56; https://doi.org/10.1038/s41409-021-01417-4Test; de Koning C, Tao W, Lacna A, van Veghel K, Horwitz ME, Sanz G, et al. Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation. Bone Marrow Transplant. 2021 Nov;56:2826–2833.; https://hdl.handle.net/11351/6921Test; 000679018100001 |
| DOI: | 10.1038/s41409-021-01417-4 |
| الإتاحة: | https://doi.org/10.1038/s41409-021-01417-4Test https://hdl.handle.net/11351/6921Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.878D2B |
| قاعدة البيانات: | BASE |
| تدمد: | 14765365 34312498 |
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| DOI: | 10.1038/s41409-021-01417-4 |