التفاصيل البيبلوغرافية
| العنوان: |
GLP-1 receptor agonists in type 1 diabetes: a proof-of-concept approach. |
| المؤلفون: |
Crisci, Isabella1, Aragona, Michele1, Politi, Konstantina1, Daniele, Giuseppe1, Prato, Stefano1 stefano.delprato@med.unipi.it |
| المصدر: |
Acta Diabetologica. Dec2015, Vol. 52 Issue 6, p1129-1133. 5p. |
| مصطلحات موضوعية: |
*C-peptide, *HYPOGLYCEMIA, *DRUG efficacy, *GLUCAGON-like peptide 1, *INSULIN therapy, *THERAPEUTICS, *DISEASE risk factors |
| مستخلص: |
Aims: To test potential efficacy of liraglutide, a GLP-1 receptor agonist, in subjects with type 1 diabetes (T1DM). Methods: We have recruited nine T1DM patients (age 40.1 ± 6.4 years, duration of diabetes 19.2 ± 8.8 years, BMI 24.3 ± 3.5 kg/m, HbA1c 8.2 ± 1.0 %-66 ± 11 mmol/mol, daily insulin dose: 0.6 ± 0.1 IU/kg) on continuous subcutaneous insulin therapy with undetectable C-peptide. In addition to existing treatment was administered in single-blind (a) therapy subcutaneously with 0.1 ml of saline solution for 3 days and (b) 0.1 ml of liraglutide (0.6 mg/day) for a further 3 days with daily glucose excursions recorded by continuous glucose monitoring. Results: Adding liraglutide resulted in a significant reduction in mean blood glucose (138 ± 29 vs. 163 ± 29 mg/dl, p < 0.0001) and standard deviation (42 ± 9 vs. 60 ± 15 mg/dl, p < 0.0001). The area under the curve (AUC) for blood glucose >140 mg/dl was also significantly reduced (22.2 ± 16.4 vs. 41.1 ± 19.7 mg/dl h, p < 0.05) with no difference in AUC for blood glucose <70 mg/dl (liraglutide 0.7 ± 0.9 mg/dl h; placebo: 0.8 ± 1.4 mg/dl h, p = NS). Finally, adding liraglutide reduced daily insulin requirement (37.5 ± 17.2 vs. 42.9 ± 22.4 UI/day, p < 0.01). Conclusions: Short-term treatment with liraglutide, in T1DM, reduces average blood glucose, blood glucose variability and daily insulin requirement without increasing risk of hypoglycemia. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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