التفاصيل البيبلوغرافية
| العنوان: |
Enhancing immunity to HIV through APOBEC. |
| المؤلفون: |
Harris, Reuben S1 |
| المصدر: |
Nature Biotechnology. Oct2008, Vol. 26 Issue 10, p1089-1090. 2p. 1 Diagram. |
| مصطلحات موضوعية: |
*AIDS vaccines, *ANTIVIRAL agents, *MOLECULES, *VIRAL replication, *SUBCELLULAR fractionation, *PROTEIN research, *PREVENTION |
| مستخلص: |
The article discusses the the human antiviral protein APOBEC3G (A3G) and its viral antagonist Vif as targets for the restriction of HIV infection in humans. Recent studies conducted on the virus found that small molecules can help the antiviral agent to avoid Vif, the viral protein that degrades A3G. One of these beneficial molecules, named RN-18, was observed to cause a dose-dependent decrease in viral replication in two human T-cell lines that express A3G. RN-18 is believed to work by promoting degradation of the subcellular fraction of Vif that is bound to an A3G protein. It is noted that HIV has an innate ability to develop resistance to anti-viral therapies and that anything modulating A3G may have undesirable side effects. |
| قاعدة البيانات: |
Academic Search Index |
