Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study
| العنوان: | Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study |
|---|---|
| المؤلفون: | Anna Pedret, Judit Companys, Rosa M. Valls, Lorena Calderón-Pérez, Laura Rubió, Nuria Jiménez-Hernández, Maria-Paz Romero, María José Gosalbes, Elisabet Llauradó, Alejandro Artacho, Rosa Solà, Laura Pla-Pagà, Silvia Yuste, Iziar A. Ludwig |
| المصدر: | Repositorio Abierto de la UdL Universitad de Lleida Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020) Scientific Reports Recercat. Dipósit de la Recerca de Catalunya instname Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| بيانات النشر: | Springer Nature, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, DNA, Bacterial, Male, 0301 basic medicine, lcsh:Medicine, Faecalibacterium prausnitzii, Blood Pressure, 030204 cardiovascular system & hematology, Gut flora, Predictive markers, Roseburia hominis, Article, Microbiology, Feces, Methylamines, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, RNA, Ribosomal, 16S, Marcadors predictius, Humans, lcsh:Science, Multidisciplinary, biology, lcsh:R, Lachnospiraceae, Middle Aged, Ribosomal RNA, Fatty Acids, Volatile, biology.organism_classification, Gastrointestinal Microbiome, Cross-Sectional Studies, 030104 developmental biology, Hypertension, Metagenome, Female, lcsh:Q, Hipertensió, Ruminococcaceae |
| الوصف: | Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development. We carried out comprehensive gut microbiota analysis and targeted metabolomics in a cross-sectional study of 29 non-treated hypertensive (HT) and 32 normotensive (NT) subjects. We determined fecal microbiota composition by 16S rRNA gene sequencing and bacterial functions by metagenomic analysis. The microbial metabolites analysed were short chain fatty acids (SCFA) both in plasma and feces, and trimethylamine N-oxide (TMAO) in plasma. The overall bacterial composition and diversity of bacterial community in the two groups were not significantly different. However, Ruminococcaceae NK4A214, Ruminococcaceae_UCG-010, Christensenellaceae_R-7, Faecalibacterium prausnitzii and Roseburia hominis were found to be significantly enriched in NT group, whereas, Bacteroides coprocola, Bacteroides plebeius and genera of Lachnospiraceae were increased in HT patients. We found a positive correlation between the HT-associated species and systolic and diastolic blood pressure after adjusted for measured confounders. SCFA showed antagonistic results in plasma and feces, detecting in HT subjects significant higher levels in feces and lower levels in plasma, which could indicate a less efficient SCFA absorption. Overall, our results present a disease classifier based on microbiota and bacterial metabolites to discriminate HT individuals from NT controls in a first disease grade prior to drug treatment. We wish to acknowledge the support of the Institut d’Investigació Sanitària Pere Virgili (IISPV) and the EURECAT-Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut (Reus, Spain), the University of Lleida through the SY grant, the LR Sara Borrell postdoctoral grant (CD14/00275), and AP Torres Quevedo contract (Subprograma Estatal de Incorporación, Plan Estatal de Investigación Científica y Técnica y de Innovación). LC was granted by Ayudas Para La Promoción De Empleo Joven E Implantación De La Garantía Juvenil En I + D + I (PEJ-2014-A-67028). NFOC-Salut group is a consolidated research group of Generalitat de Catalunya, Spain (2017 SGR522). |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8c845aa6c8c3cad287719b6f30467dTest https://hdl.handle.net/10459.1/68531Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0a8c845aa6c8c3cad287719b6f30467d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |