التفاصيل البيبلوغرافية
| العنوان: |
Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients. |
| المؤلفون: |
Zhang, Yan, Wang, Jin, Zhao, Li-Mei, Peng, Wei, Shen, Guo-Qing, Xue, Ling, Zheng, Xiao-Xian, HE, Xiao-Jing, Gong, Chun-Yan, Miao, Li-Yan |
| المصدر: |
European Journal of Clinical Pharmacology; Sep2011, Vol. 67 Issue 9, p885-887, 3p, 1 Chart |
| مصطلحات موضوعية: |
ACADEMIC medical centers, ANALYSIS of variance, CARBAMAZEPINE, CHI-squared test, FISHER exact test, GENES, GENETIC techniques, POLYMERASE chain reaction, RESEARCH funding, TOXIC epidermal necrolysis, STEVENS-Johnson Syndrome, GENETICS |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Purpose: The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population. Methods: HLA-B*1502 genotyping with sequence-specific primer polymerase chain reaction (PCR-SSP) and PCR-sequencing based typing (PCR-SBT) was performed on 17 CBZ-induced SJS/TEN patients, 21 CBZ-tolerant controls, and 185 healthy controls recruited during 2008-2010. Results: HLA-B*1502 allele was present in 94.1% (16/17) of CBZ-SJS/TEN patients, 9.5% (2/21) of CBZ-tolerant patients, and 9.2% (17/185) of healthy controls. The risk of CBZ-induced SJS/TEN was significantly higher ( P < 0.01) in the patients with HLA-B*1502. One CBZ-induced SJS patient tested negative for HLA-B*1502, and the test result showed HLA-B*3503/B*4601. Conclusions: We found a strong association between HLA-B*1502 and CBZ-induced SJS/TEN in the Han Chinese population from central and northern China. Combined with previous studies of the southern Han Chinese subpopulation, our results suggest that HLA-B*1502 is strongly associated with CBZ-induced SJS/TEN in the whole Han Chinese population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
