التفاصيل البيبلوغرافية
| العنوان: |
Interaction of Vaccination and Reduction of Antibiotic Use Drives Unexpected Increase of Pneumococcal Meningitis. |
| المؤلفون: |
de Cellès, Matthieu Domenech, Pons-Salort, Margarita, Varon, Emmanuelle, Vibet, Marie-Anne, Ligier, Caroline, Letort, Véronique, Opatowski, Lulla, Guillemot, Didier |
| المصدر: |
Scientific Reports; 6/12/2015, p11293, 1p |
| مصطلحات موضوعية: |
DRUG interactions, EFFECT of drugs on streptococcus pneumoniae, PNEUMOCOCCAL meningitis, PHARMACEUTICAL policy, DRUG resistance, VACCINATION |
| مستخلص: |
Antibiotic-use policies may affect pneumococcal conjugate-vaccine effectiveness. The reported increase of pneumococcal meningitis from 2001 to 2009 in France, where a national campaign to reduce antibiotic use was implemented in parallel to the introduction of the 7-valent conjugate vaccine, provides unique data to assess these effects. We constructed a mechanistic pneumococcal transmission model and used likelihood to assess the ability of competing hypotheses to explain that increase. We find that a model integrating a fitness cost of penicillin resistance successfully explains the overall and age-stratified pattern of serotype replacement. By simulating counterfactual scenarios of public health interventions in France, we propose that this fitness cost caused a gradual and pernicious interaction between the two interventions by increasing the spread of nonvaccine, penicillin-susceptible strains. More generally, our results indicate that reductions of antibiotic use may counteract the benefits of conjugate vaccines introduced into countries with low vaccine-serotype coverages and high-resistance frequencies. Our findings highlight the key role of antibiotic use in vaccine-induced serotype replacement and suggest the need for more integrated approaches to control pneumococcal infections. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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