التفاصيل البيبلوغرافية
| العنوان: |
Developmental genetics of the female reproductive tract in mammals. |
| المؤلفون: |
Akio Kobayashi1, Behringer, Richard R.1 rrb@mdanderson.org |
| المصدر: |
Nature Reviews Genetics. Dec2003, Vol. 4 Issue 12, p969-980. 12p. 5 Diagrams, 2 Charts. |
| مصطلحات موضوعية: |
*DEVELOPMENTAL genetics, *FEMALE reproductive organs, *FEMALE infertility, *FERTILIZATION (Biology), *HUMAN abnormalities |
| مستخلص: |
The female reproductive tract receives the oocytes for fertilization, supports the development of the fetus and provides the passage for birth. Although abnormalities of this organ system can result in infertility and even death, until recently relatively little was known about the genetic processes that underlie its development. By drawing primarily on mouse mutagenesis studies and the analysis of human mutations we review the emerging genetic pathways that regulate female reproductive-tract formation in mammals and that are implicated in congenital abnormalities of this organ system. We also show that these pathways might be conserved between invertebrates and mammals. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
