Large-scale genotyping identifies 41 new loci associated with breast cancer risk
| العنوان: | Large-scale genotyping identifies 41 new loci associated with breast cancer risk |
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| المؤلفون: | Michailidou, K., Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R.L., Schmidt, M.K., Chang-Claude, J., Bojesen, S.E., Bolla, M.K., Wang, Q., Dicks, E., Lee, A., Turnbull, C., Rahman, N., Fletcher, O., Peto, J., Gibson, L., Silva, I.D., Nevanlinna, H., Muranen, T.A., Aittomaki, K., Blomqvist, C., Czene, K., Irwanto, A., Liu, J.J., Waisfisz, Q., Meijers-Heijboer, H., Adank, M., Luijt, R.B. van der, Hein, R., Dahmen, N., Beckman, L., Meindl, A., Schmutzler, R.K., Muller-Myhsok, B., Lichtner, P., Hopper, J.L., Southey, M.C., Makalic, E., Schmidt, D.F., Uitterlinden, A.G., Hofman, A., Hunter, D.J., Chanock, S.J., Vincent, D., Bacot, F., Tessier, D.C., Canisius, S., Wessels, L.F.A., Haiman, C.A., Shah, M., Luben, R., Brown, J., Luccarini, C., Schoof, N., Humphreys, K., Li, J.M., Nordestgaard, B.G., Nielsen, S.F., Flyger, H., Couch, F.J., Wang, X.S., Vachon, C., Stevens, K.N., Lambrechts, D., Moisse, M., Paridaens, R., Christiaens, M.R., Rudolph, A., Nickels, S., Flesch-Janys, D., Johnson, N., Aitken, Z., Aaltonen, K., Heikkinen, T., Broeks, A., Van't Veer, L.J., Schoot, C.E. van der, Guenel, P., Truong, T., Laurent-Puig, P., Menegaux, F., Marme, F., Schneeweiss, A., Sohn, C., Burwinke, B., Zamora, M.P., Perez, J.I.A., Pita, G., Alonso, M.R., Cox, A., Brock, I.W., Cross, S.S., Reed, M.W.R., Sawyer, E.J., Tomlinson, I., Kerin, M.J., Miller, N., Henderson, B.E., Schumacher, F., Marchand, L. le, Andrulis, I.L., Knight, J.A., Glendon, G., Mulligan, A.M., Lindblom, A., Margolin, S., Hooning, M.J., Hollestelle, A., Ouweland, A.M.W. van den, Jager, A., Bui, Q.M., Stone, J., Dite, G.S., Apicella, C., Tsimiklis, H., Giles, G.G., Severi, G., Baglietto, L., Fasching, P.A., Haeberle, L., Ekici, A.B., Beckmann, M.W., Brenner, H., Muller, H., Arndt, V., Stegmaier, C., Swerdlown, A., Ashworth, A., Orr, N., Jones, M., Figueroa, J., Lissowska, J., Brinton, L., Goldberg, M.S., Labreche, F., Dumont, M., Winqvist, R., Pylkas, K., Jukkola-Vuorinen, A., Grip, M., Brauch, H., Hamann, U., Bruning, T., Radice, P., Peterlongo, P., Manouldan, S., Bonanni, B., Devilee, P., Tollenaar, R.A.E.M., Seynaeve, C., Asperen, C.J. van, Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Mannermaa, A., Kataja, V., Kosma, V.M., Hartikainen, J.M., Bogdanova, N.V., Antonenkova, N.N., Dork, T., Kristensen, V.N., Anton-Culver, H., Slager, S., Toland, A.E., Edge, S., Fostira, F., Kang, D., Yoo, K.Y., Noh, D.Y., Matsuo, K., Ito, H., Iwata, H., Sueta, A., Wu, A.H., Tseng, C.C., Berg, D. van den, Stram, D.O., Shu, X.O., Lu, W., Gao, Y.T., Cai, H., Teo, S.H., Yip, C.H., Phuah, S.Y., Cornes, B.K., Hartman, M., Miao, H., Lim, W.Y., Sng, J.H., Muir, K., Lophatananon, A., Stewart-Brown, S., Siriwanarangsan, P., Shen, C.Y., Hsiung, C.N., Wu, P.E., Ding, S.L., Sangrajrang, S., Gaborieau, V., Brennan, P., Mckay, J., Blot, W.J., Signorello, L.B., Cai, Q.Y., Zheng, W., Deming-Halverson, S., Shrubsole, M., Long, J.R., Simard, J., Garcia-Closas, M., Pharoah, P.D.P., Chenevix-Trench, G., Dunning, A.M., Benitez, J., Easton, D.F., Breast Ovarian Canc Susceptibility, Hereditary Breast Ovarian Canc Res, kConFab Investigators, Australian Ovarian Can Study Grp, GENICA Gene Environm Interaction B |
| المساهمون: | CCA -Cancer Center Amsterdam, ARD - Amsterdam Reproduction and Development, Human Genetics, Landsteiner Laboratory, Clinical Haematology, Clinical Genetics, Internal Medicine, Epidemiology, Medical Oncology, Cardiothoracic Surgery, Human genetics, CCA - Oncogenesis, ~ |
| المصدر: | Nature genetics, 45(4). Nature Publishing Group Nature Genetics; Vol 45 Nature Genetics, 45(4), 353-361 Nature Genetics, 45(4), 353-361. Nature Publishing Group Michailidou, K, Hall, P, Gonzalez-Neira, A, Ghoussaini, M, Dennis, J, Milne, R L, Schmidt, M K, Chang-Claude, J, Bojesen, S E, Bolla, M K, Wang, Q, Dicks, E, Lee, A, Turnbull, C, Rahman, N, Fletcher, O, Peto, J, Gibson, L, Silva, I D, Nevanlinna, H, Muranen, T A, Aittomaki, K, Blomqvist, C, Czene, K, Irwanto, A, Liu, J J, Waisfisz, Q, Meijers-Heijboer, H, Adank, M, van der Luijt, R B, Hein, R, Dahmen, N, Beckman, L, Meindl, A, Schmutzler, R K, Muller-Myhsok, B, Lichtner, P, Hopper, J L, Southey, M C, Makalic, E, Schmidt, D F, Uitterlinden, A G, Hofman, A, Hunter, D J, Chanock, S J, Vincent, D, Bacot, F, Tessier, D C, Canisius, S, Wessels, L F A, Haiman, C A, Shah, M, Luben, R, Brown, J C, Luccarini, C, Schoof, N, Humphreys, K, Li, J M, Nordestgaard, B G, Nielsen, S F, Flyger, H, Couch, F J, Wang, X S, Vachon, C, Stevens, K N, Lambrechts, D, Moisse, M, Paridaens, R, Christiaens, M R, Rudolph, A, Nickels, S, Flesch-Janys, D, Johnson, N, Aitken, Z, Aaltonen, K, Heikkinen, T, Broeks, A, van 't Veer, L J, van der Schoot, C E, Guenel, P, Truong, T, Laurent-Puig, P, Menegaux, F, Marme, F, Schneeweiss, A, Sohn, C, Burwinke, B, Zamora, M P, Perez, J I A, Pita, G, Alonso, M R, Cox, A, Brock, I W, Cross, S S, Reed, M W R, Sawyer, E J, Tomlinson, I, Kerin, M J, Miller, N, Benitez, J & Easton, D F 2013, ' Large-scale genotyping identifies 41 new loci associated with breast cancer risk ', Nature Genetics, vol. 45, no. 4, pp. 353-361 . https://doi.org/10.1038/ng.2563Test Nature Genetics |
| بيانات النشر: | Springer Nature, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | signaling pathway, Genotyping, Genotype, Single-nucleotide polymorphism, Genome-wide association study, Breast Neoplasms, consortium, Biology, Case-Control Studies, Cooperative Behavior, Female, Gene-Environment Interaction, Genetic Loci, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Risk Factors, Genetic Predisposition to Disease, Genetics, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, SDG 3 - Good Health and Well-being, common variants, expression, medicine, Polymorphism, gene, hormone-related protein, 030304 developmental biology, Genetic association, 0303 health sciences, Breast cancer susceptibility, Cancer, Single Nucleotide, medicine.disease, confer susceptibility, susceptibility loci, 3. Good health, 14q24.1 rad51l1, TOX3, 030220 oncology & carcinogenesis, genome-wide association |
| الوصف: | Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10!¿8). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility. European Community Seventh Framework Programme - grant agreement 223175 (HEALTH-F2-2009-223175) (COGS) peer-reviewed |
| وصف الملف: | application/doc |
| تدمد: | 1061-4036 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ce99d85e1e04916e33425529f5e91Test http://hdl.handle.net/10379/12885Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e67ce99d85e1e04916e33425529f5e91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10614036 |
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