التفاصيل البيبلوغرافية
| العنوان: |
Association of HLA alleles and haplotypes with vitiligo in Moroccan patients: a case–control study. |
| المؤلفون: |
Bouayad, Abdellatif, Benzekri, L., Hamada, S., Brick, C., Hassam, B., Essakalli, M. |
| المصدر: |
Archives of Dermatological Research; Dec2013, Vol. 305 Issue 10, p925-932, 8p |
| مصطلحات موضوعية: |
HLA class II antigens, ALLELES, HAPLOTYPES, MOROCCANS, VITILIGO, POLYMERASE chain reaction, PATIENTS, DISEASES |
| مستخلص: |
The aim of this study was to identify HLA class II alleles that may be involved in vitiligo genetic susceptibility in the Moroccan population and to determine susceptible and protective HLA alleles/haplotypes in vitiligo. One-hundred unrelated vitiligo patients and 300 healthy unrelated controls were studied for HLA class II alleles by polymerase chain reaction-sequence-specific primers. The phenotypic frequency of DRB1*07 (OR = 2.23, pc = 0.014) was significantly higher, while that of DRB1*03 (OR = 0.40, pc = 0.014) was significantly lower in patients than in controls. Haplotype DRB1*07 –DQB1*02 (OR = 2.25, pc = 0.024) was positively associated with vitiligo patients, while haplotype DRB1*03 –DQB1*02 (OR = 0.35, pc = 0.012) was negatively associated with this group. Vitiligo patients with positive family history and negative anti-thyroid peroxidase antibody (anti-TPO) have an extremely high phenotype frequency of DRB1*07 –DQB1*02 haplotype (OR = 2.91, pc = 0.048 and OR = 2.62, pc = 0.00475, respectively). DRB1*03 –DQB1*02 (OR = 0.32, pc = 0.048 and OR = 0.38, pc = 0.048, respectively) was negatively associated with patients without a family history and negative anti-TPO. This study demonstrated the positive association of HLA class II alleles and haplotypes with vitiligo in the Moroccan population. There may be differences in HLA haplotypes distribution in patients according to family history and anti-TPO profile. [ABSTRACT FROM AUTHOR] |
|
Copyright of Archives of Dermatological Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
