التفاصيل البيبلوغرافية
| العنوان: |
A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR. |
| المؤلفون: |
Cleary, James M., Calvo, Emiliano, Moreno, Victor, Juric, Dejan, Shapiro, Geoffrey I., Vanderwal, Carol Ann, Hu, Beibei, Gifford, Maryella, Barch, David, Roberts-Rapp, Lisa, Ansell, Peter J., Xiong, Hao, Ocampo, Christopher, Tolcher, Anthony W. |
| المصدر: |
Investigational New Drugs; Oct2020, Vol. 38 Issue 5, p1483-1494, 12p |
| مصطلحات موضوعية: |
ANTINEOPLASTIC agents, CLINICAL trials, EPIDERMAL growth factor, IMMUNOHISTOCHEMISTRY, MEDICAL cooperation, MONOCLONAL antibodies, RESEARCH, TUMORS, TREATMENT effectiveness, DESCRIPTIVE statistics, CHEMICAL inhibitors |
| مستخلص: |
Summary: Losatuxizumab vedotin (formerly ABBV-221) is a second-generation antibody-drug conjugate targeting epidermal growth factor receptor (EGFR). In this multicenter phase 1 study, eligible patients with EGFR-dependent solid tumors received losatuxizumab vedotin (3 + 3 design) intravenously at starting dose of 0.3 mg/kg over 3 h per 21-day cycle, with alternate dosing schedules utilized (2 weeks on/1 week off or weekly) to mitigate infusion reactions. Forty-five patients received ≥1 doses of losatuxizumab vedotin (13 colon, 6 non-small cell lung cancer, 5 head and neck [HNC], 5 glioblastoma multiforme, 2 breast, 14 other). Tumor samples were evaluated for EGFR protein expression by immunohistochemistry, EGFR and EGFR ligand mRNA expression by RNAseq, and results compared with outcome. Most common adverse events were infusion-related reaction (22/45; 49%) and fatigue (20/45; 44%). While most infusion reactions were grade ≤ 2, four patients experienced grade ≥3 infusion reactions. Several infusion reaction mitigation strategies were explored. Because of the high incidence of infusion reactions, the trial was stopped and the maximum tolerated dose was not reached. The last cleared dose: 6 mg/kg/cycle. Nineteen patients (42%) had stable disease; 4 remained on study >6 months. One HNC patient with increased levels of EGFR and EGFR ligands (amphiregulin, epiregulin) achieved a confirmed partial response. Pharmacokinetic analysis of losatuxizumab vedotin showed exposures appeared to be approximately dose-proportional. The high frequency of infusion reactions necessitated early closure of this trial. The detailed mitigation strategies used in this protocol for infusion-related reactions may provide beneficial information for trial design of agents with high infusion reaction rates. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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