المؤلفون: Jeffrey P. Krischer, David Boulware, Polly J. Bingley

المصدر: Diabetologia
Bingley, P J, Boulware, D C, Krischer, J P 2016, ' The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance : development of other autoantibodies and progression to type 1 diabetes ', Diabetologia, vol. 59, no. 3, pp. 542–549 . https://doi.org/10.1007/s00125-015-3830-2Test

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Zinc transporter 8, Human leukocyte antigen, Zinc Transporter 8, Autoantigens, Article, 03 medical and health sciences, Insulin autoantibodies, Islets of Langerhans, Young Adult, 0302 clinical medicine, Antigen, medicine, Internal Medicine, Humans, Young adult, Child, Cation Transport Proteins, Diabetes antibodies, Autoantibodies, Normal glucose tolerance, Type 1 diabetes, geography, geography.geographical_feature_category, business.industry, GAD, Prevention, Autoantibody, Islet autoantibodies, medicine.disease, Islet, 3. Good health, HLA, 030104 developmental biology, IA-2, Diabetes Mellitus, Type 1, Immunology, Disease Progression, Female, business, Prediction

الوصف: Aims/hypothesis Autoantibodies directed at single islet autoantigens are associated with lower overall risk of type 1 diabetes than multiple autoantibodies, but individuals with one autoantibody may progress to higher risk categories. We examined the characteristics of this progression in relatives followed prospectively in the TrialNet Pathway to Prevention. Methods The study population comprised 983 relatives who were single autoantibody positive with normal baseline glucose tolerance (median age 16.2 years). Samples were screened for antibodies to GAD, insulinoma-associated antigen 2 (IA-2) and insulin, and all positive samples tested for antibodies to zinc transporter 8 and islet cell antibodies. Results Antibodies to at least one additional islet autoantigen appeared in 118 of 983 relatives (overall 5 year risk 22%, 95% CI [17.9, 26.1]). At baseline, antibodies to GAD alone (68%) were more frequent than antibodies to insulin (26%) or IA-2 (6%), but all were associated with a similar risk of developing additional autoantibodies. Risk was associated with younger age (p = 0.002) and HLA class II genotype, but was similar in high and intermediate genetic risk groups (p = 0.65). Relatives who became multiple autoantibody positive during the follow-up had increased risk of developing diabetes comparable with the risk in relatives with multiple autoantibodies at study entry. Conclusions/interpretation Progression of islet autoimmunity in single autoantibody positive relatives in late childhood/adult life is associated with a predominance of autoantibodies to GAD and a distinct HLA risk profile. This heterogeneity in type 1 diabetes autoimmunity has potentially important implications for disease prevention. Electronic supplementary material The online version of this article (doi:10.1007/s00125-015-3830-2) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

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المؤلفون: Ulrike Schierloh, Tadej Battelino, Ignacio Conget, I. Schütz-Fuhrmann, R. Hoogma, Eva Hommel, N. Sulli, Jan Bolinder, Birgitte B. Olsen

المصدر: Diabetologia

مصطلحات موضوعية: Insulin pump, Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Adolescent, Endocrinology, Diabetes and Metabolism, Continuous glucose monitoring, Diabetes mellitus type 1, Glycaemic control, Insulin pump therapy, Randomised controlled trial, Sensor-augmented insulin pump therapy, Aged, Biosensing Techniques, Blood Glucose Self-Monitoring, Child, Cross-Over Studies, Diabetes Mellitus, Type 1, Female, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Middle Aged, Monitoring, Physiologic, Treatment Outcome, Insulin Infusion Systems, Internal Medicine, Article, law.invention, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, medicine, Intensive care medicine, Type 1 diabetes, business.industry, medicine.disease, Crossover study, Multicenter study, business

الوصف: Aims/hypothesis The aim of this multicentre, randomised, controlled crossover study was to determine the efficacy of adding continuous glucose monitoring (CGM) to insulin pump therapy (CSII) in type 1 diabetes. Methods Children and adults (n = 153) on CSII with HbA1c 7.5–9.5% (58.5–80.3 mmol/mol) were randomised to (CGM) a Sensor On or Sensor Off arm for 6 months. After 4 months’ washout, participants crossed over to the other arm for 6 months. Paediatric and adult participants were separately electronically randomised through the case report form according to a predefined randomisation sequence in eight secondary and tertiary centres. The primary outcome was the difference in HbA1c levels between arms after 6 months. Results Seventy-seven participants were randomised to the On/Off sequence and 76 to the Off/On sequence; all were included in the primary analysis. The mean difference in HbA1c was –0.43% (–4.74 mmol/mol) in favour of the Sensor On arm (8.04% [64.34 mmol/mol] vs 8.47% [69.08 mmol/mol]; 95% CI −0.32%, −0.55% [−3.50, −6.01 mmol/mol]; p

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المؤلفون: Raimundo Celestino Silva Neves, Ana Beatriz Valverde Mendes, João Antônio Saraiva Fittipaldi, Antônio Roberto Chacra, Edson D. Moreira

المساهمون: Brazilian Minist Hlth, Universidade Federal de São Paulo (UNIFESP), Pfizer Inc, Charitable Works Fdn Sister

المصدر: Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Acta Diabetologica

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Pediatrics, HbA1c, Adolescent, Epidemiology, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Young Adult, Diabetes mellitus, Endocrinology, Patient Education as Topic, Surveys and Questionnaires, Glycaemic control, Health care, Ethnicity, medicine, Internal Medicine, Humans, Hypoglycemic Agents, Insulin, HbA(1c), Aged, Glycated Hemoglobin, Type 1 diabetes, business.industry, Patient Selection, Public health, Racial Groups, General Medicine, Middle Aged, medicine.disease, Health Surveys, Surgery, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Original Article, Female, Health education, business, Brazil

الوصف: Pfizer Inc., Brazil Diabetes is a significant public health burden on the basis of its increased incidence, morbidity, and mortality. This study aimed to estimate the prevalence of inadequate glycaemic control and its correlates in a large multicentre survey of Brazilian patients with diabetes. A cross-sectional study was conducted in a consecutive sample of patients aged 18 years or older with either type 1 or type 2 diabetes, attending health centres located in ten large cities in Brazil (response rate = 84%). Information about diabetes, current medications, complications, diet, and satisfaction with treatment were obtained by trained interviewers, using a standardized questionnaire. Glycated haemoglobin (HbA(1c)) was measured by high-performance liquid chromatography in a central laboratory. Patients with HbA(1c) a parts per thousand yen 7 were considered to have inadequate glycaemic control. Overall 6,701 patients were surveyed, 979 (15%) with type 1 and 5,692 (85%) with type 2 diabetes. the prevalence of inadequate glycaemic control was 76%. Poor glycaemic control was more common in patients with type 1 diabetes (90%) than in those with type 2 (73%), P < 0.001. Characteristics significantly associated with improved glycaemic control included: fewer years of diabetes duration, multi professional care, participation in a diabetes health education program, and satisfaction with current diabetes treatment. Despite increased awareness of the benefits of tight glycaemic control, we found that few diabetic patients in Brazil met recommended glycaemic control targets. This may contribute to increased rates of diabetic complications, which may impact health care costs. Our data support the public health message of implementation of early, aggressive management of diabetes. Brazilian Minist Hlth, Oswaldo Cruz Fdn, Goncalo Moniz Res Ctr, BR-40296710 Salvador, BA, Brazil Universidade Federal de São Paulo, BR-04023900 São Paulo, Brazil Pfizer Inc, BR-04717904 São Paulo, Brazil Charitable Works Fdn Sister, Clin Res Ctr, BR-40415006 Salvador, BA, Brazil Universidade Federal de São Paulo, BR-04023900 São Paulo, Brazil Web of Science

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المؤلفون: Magdalena Szopa, Malgorzata Urbanska-Kosinska, Maciej Borowiec, Manfredi Rizzo, Karolina Antosik, Agnieszka Szadkowska, Beata Małachowska, Maciej T. Malecki, Maciej Banach, Wojciech Młynarski, Wojciech Fendler

المصدر: Acta Diabetologica

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Biology, Lipid subpopulations, Young Adult, chemistry.chemical_compound, Endocrinology, Monogenic diabetes, Internal medicine, Diabetes mellitus, Glucokinase, medicine, Internal Medicine, Humans, Hepatocyte Nuclear Factor 1-alpha, Child, Type 1 diabetes, medicine.diagnostic_test, Cholesterol, Cholesterol, HDL, Case-control study, nutritional and metabolic diseases, Cholesterol, LDL, General Medicine, medicine.disease, Lipoproteins, LDL, Diabetes Mellitus, Type 1, chemistry, Case-Control Studies, Metabolic control analysis, MODY, Original Article, Female, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, Lipid profile, Lipoprotein

الوصف: Patients with diabetes caused by single-gene mutations generally exhibit an altered course of diabetes. Those with mutations of the glucokinase gene (GCK-MODY) show good metabolic control and low risk of cardiovascular complications despite paradoxically lowered high-density lipoprotein (HDL) cholesterol levels. In order to investigate the matter, we analyzed the composition of low-density lipoprotein (LDL) and HDL subpopulations in such individuals. The LipoPrint(©) system (Quantimetrix, USA) based on non-denaturing, linear polyacrylamide gel electrophoresis was used to separate and measure LDL and HDL subclasses in fresh-frozen serum samples from patients with mutations of glucokinase or HNF1A, type 1 diabetes (T1DM) and healthy controls. Fresh serum samples from a total of 37 monogenic diabetes patients (21 from GCK-MODY and 16 from HNF1A-MODY), 22 T1DM patients and 15 healthy individuals were measured in this study. Concentrations of the small, highly atherogenic LDL subpopulation were similar among the compared groups. Large HDL percentage was significantly higher in GCK-MODY than in control (p = 0.0003), T1DM (p = 0.0006) and HNF1A-MODY groups (p = 0.0246). Patients with GCK-MODY were characterized by significantly lower intermediate HDL levels than controls (p = 0.0003) and T1DM (p = 0.0005). Small, potentially atherogenic HDL content differed significantly with the GCK-MODY group showing concentrations of that subfraction from control (p = 0.0096), T1DM (p = 0.0193) and HNF1A-MODY (p = 0.0057) groups. Within-group heterogeneity suggested the existence of potential gene-gene or gene-environment interactions. GCK-MODY is characterized by a strongly protective profile of HDL cholesterol subpopulations. A degree of heterogeneity within the groups suggests the existence of interactions with other genetic or clinical factors.

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المؤلفون: Mo-Li Yang, Hong Guo, Lijuan Wu, Yanli Qi, Yongchao Chang, Dandan Feng, Fong-Fong Chu, Qiang Gao, Hong-Qian Li, Lei Gao, Yufeng Zheng, Pan Chen, Yunfeng Zhou, Hao Guo

المصدر: Digestive Diseases and Sciences

مصطلحات موضوعية: Male, 0301 basic medicine, Physiology, Gastroenterology, Dual oxidase-2 (DUOX2), Pathogen, Membrane Glycoproteins, NADPH oxidase, biology, Lactoperoxidase (LPO), NADPH Oxidase 1, Middle Aged, Antibodies, Bacterial, Dual Oxidases, Immunohistochemistry, medicine.anatomical_structure, Gastritis, NADPH Oxidase 2, Original Article, Female, medicine.symptom, Adult, Gastritis, Atrophic, Peptic Ulcer, medicine.medical_specialty, Adolescent, Helicobacter pylori (H. pylori), Blotting, Western, Enzyme-Linked Immunosorbent Assay, Real-Time Polymerase Chain Reaction, Helicobacter Infections, Microbiology, Young Adult, 03 medical and health sciences, NOX2, Bacterial Proteins, Internal medicine, Gastric mucosa, medicine, Humans, CagA, Lactoperoxidase, RNA, Messenger, Aged, Peroxidase, Antigens, Bacterial, Helicobacter pylori, NADPH Oxidases, Dual oxidase 2, bacterial infections and mycoses, biology.organism_classification, 030104 developmental biology, Immunoglobulin G, biology.protein

الوصف: Background Helicobacter pylori (H. pylori) is a well-recognized gastroduodenal pathogen and class I carcinogen. Dual oxidase-2 (DUOX2), a member of NADPH oxidase family, has several critical physiological functions, including thyroid hormone biosynthesis and host mucosal defense. Aim To investigate the effect of H. pylori infection on DUOX2 gene expression in human stomach. Materials and Methods The biopsies were obtained from patients who underwent endoscopic diagnosis. The patient serum was assayed for two virulence factors of H. pylori, CagA IgG and VacA. The inflammation in gastric mucosa was analyzed with histology. Real-time quantitative PCR was used to detect the expression of three members of NADPH oxidase, NOX1, NOX2, and DUOX2, as well as lactoperoxidase (LPO) in the gastric mucosa. NOX2, DUOX2, and myeloperoxidase (MPO) protein levels were quantified by Western blots or immunohistochemistry. Results The H. pylori-infected gastric mucosa had more severe inflammation than uninfected samples. However, the expression of DUOX2 mRNA and protein was lower in gastric mucosa of patients with H. pylori infection compared to the uninfected. Among the H. pylori-infected patients, those having CagA IgG or VacA in the serum had lower DUOX2 expression levels than those infected with H. pylori without either virulence factor. The NOX2 and MPO levels were higher in those patients infected with H. pylori irrespective of the virulence factors than those uninfected patients. NOX1 and LPO mRNA were undetectable in the gastric mucosa. Conclusion CagA+ or VacA+ H. pylori in the stomach of patients may suppress DUOX2 expression to promote its own survival. Increased NOX2 could not eliminate H. pylori infection. Electronic supplementary material The online version of this article (doi:10.1007/s10620-016-4144-z) contains supplementary material, which is available to authorized users.

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المؤلفون: Downes, Kate, Marcovecchio, M Loredana, Clarke, Pamela, Cooper, Jason D, Ferreira, Ricardo C, Howson, Joanna MM, Jolley, Jennifer, Nutland, Sarah, Stevens, Helen E, Walker, Neil M, Wallace, Chris, Dunger, David B, Todd, John A

المساهمون: Downes, Kate [0000-0003-0366-1579], Marcovecchio, Loredana [0000-0002-4415-316X], Howson, Joanna [0000-0001-7618-0050], Wallace, Chris [0000-0001-9755-1703], Dunger, David [0000-0002-2566-9304], Apollo - University of Cambridge Repository

المصدر: Diabetologia. 57(2):366-372

مصطلحات موضوعية: Adult, Immunoassay, Inflammation, Male, Adolescent, C-Peptide, Endocrinology, Diabetes and Metabolism, Interleukin-2 Receptor alpha Subunit, Middle Aged, Diabetes Mellitus, Type 1, Case-Control Studies, Insulin-Secreting Cells, Disease Progression, Internal Medicine, Humans, Female, Biomarkers, Aged

الوصف: AIMS/HYPOTHESIS: Type 1 diabetes is a common autoimmune disease that has genetic and environmental determinants. Variations within the IL2 and IL2RA (also known as CD25) gene regions are associated with disease risk, and variation in expression or function of these proteins is likely to be causal. We aimed to investigate if circulating concentrations of the soluble form of CD25, sCD25, an established marker of immune activation and inflammation, were increased in individuals with type 1 diabetes and if this was associated with the concentration of C-peptide, a measure of insulin production that reflects the degree of autoimmune destruction of the insulin-producing beta cells. METHODS: We used immunoassays to measure sCD25 and C-peptide in peripheral blood plasma from patient and control samples. RESULTS: We identified that sCD25 was increased in patients with type 1 diabetes compared with controls and replicated this result in an independent set of 86 adult patient and 80 age-matched control samples (p = 1.17 × 10(-3)). In 230 patients under 20 years of age, with median duration-of-disease of 6.1 years, concentrations of sCD25 were negatively associated with C-peptide concentrations (p = 4.8 × 10(-3)). CONCLUSIONS/INTERPRETATION: The 25% increase in sCD25 in patients, alongside the inverse association between sCD25 and C-peptide, probably reflect the adverse effects of an on-going, actively autoimmune and inflammatory immune system on beta cell function in patients.

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المؤلفون: Toshirou Nishida, Mari Wataya-Kaneda, Seiichi Hirota, Tsuyoshi Takahashi, Jean-Yves Blay, Masahiko Tsujimoto

المصدر: Journal of Gastroenterology

مصطلحات موضوعية: Adult, Male, Original Article—Alimentary Tract, medicine.medical_specialty, Pathology, congenital, hereditary, and neonatal diseases and abnormalities, Stromal cell, Neurofibromatosis 1, Adolescent, Gastrointestinal Stromal Tumors, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Asian People, Japan, Surgical oncology, Internal medicine, Multidetector Computed Tomography, medicine, Prevalence, Humans, Young adult, neoplasms, Aged, Gastrointestinal Neoplasms, Retrospective Studies, Neurofibromatosis type I, Aged, 80 and over, business.industry, Gastroenterology, Retrospective cohort study, Hepatology, Middle Aged, medicine.disease, Prognosis, Colorectal surgery, eye diseases, digestive system diseases, 3. Good health, nervous system diseases, 030220 oncology & carcinogenesis, Clinicopathologic features, 030211 gastroenterology & hepatology, Female, Radiology, Gastrointestinal stromal tumor, business, Abdominal surgery

الوصف: Background Neurofibromatosis type I (NF1) predisposes patients to various neoplasias, including gastrointestinal stromal tumors (GISTs). Little is known about the risk of developing GISTs for NF1 patients or the clinicopathologic features and prognosis of NF1-GIST. Methods We conducted a multi-detector computed tomography screen for adult NF1 patients between 2003 and 2012. Clinicopathologic data of sporadic GISTs from patients who underwent surgery between 2001 and 2010 were retrospectively collected from 32 hospitals in Japan. Results CT screening identified 6 GIST patients from the 95 NF1 patients screened, suggesting that the prevalence rate of GISTs was approximately 6.3/100 in NF1 patients. All 6 NF1 patients exhibited hyperplasia of the interstitial cells of Cajal in the adjoining small intestine. NF1-GISTs may account for 1.1–1.3 % of primary sporadic GISTs and present as multiple tumors in the small intestine, with low mitotic activity and no KIT or PDGFRA mutations. The risk of recurrence and mortality is very similar between NF1 and non-NF1 patients after surgical resection of GISTs. Conclusions NF1 patients may be predisposed to developing small intestinal GISTs, which may appear as multiple GISTs without KIT and PDGFRA mutations. The prognosis of patients with NF1-GISTs is similar to patients with conventional GISTs. Electronic supplementary material The online version of this article (doi:10.1007/s00535-015-1132-6) contains supplementary material, which is available to authorized users.

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المؤلفون: Jan Buter, Jaap C. Reijneveld, Jaco C. Knol, Connie R. Jimenez, Laurine E. Wedekind, Esther Sanchez Aliaga, Thang V. Pham, Koos E. Hovinga, Myra E. van Linde, Johannes C. van der Mijn, Henk M.W. Verheul

المساهمون: Internal medicine, CCA - Innovative therapy, CCA - Quality of life, Medical oncology, Medical oncology laboratory, CCA - Disease profiling, CCA - Oncogenesis, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Neurology

المصدر: van Linde, M E, van der Mijn, J C, Pham, T V, Knol, J C, Wedekind, L E, Hovinga, K E, Aliaga, E S, Buter, J, Jimenez, C R, Reijneveld, J C & Verheul, H M W 2016, ' Evaluation of potential circulating biomarkers for prediction of response to chemoradiation in patients with glioblastoma ', Journal of Neuro-Oncology, vol. 129, no. 2, pp. 221-30 . https://doi.org/10.1007/s11060-016-2178-xTest
Journal of Neuro-Oncology, 129(2), 221-30. Kluwer Academic Publishers
Journal of Neuro-Oncology

مصطلحات موضوعية: Proteomics, Male, 0301 basic medicine, Oncology, Cancer Research, alpha-2-HS-Glycoprotein, Cohort Studies, 0302 clinical medicine, Adrenal Cortex Hormones, Outcome Assessment, Health Care, Young adult, biology, Brain Neoplasms, Haptoglobin, Chemoradiotherapy, Middle Aged, Treatment Outcome, Neurology, 030220 oncology & carcinogenesis, Cohort, Biomarker (medicine), Female, Cohort study, Adult, Blood Platelets, medicine.medical_specialty, Adolescent, First-line treatment, Clinical Neurology, Glioblastoma multiforme, Disease-Free Survival, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Chitinase-3-Like Protein 1, Progression-free survival, Aged, Haptoglobins, business.industry, Biomarker, Surgery, 030104 developmental biology, Laboratory Investigation, biology.protein, Neurology (clinical), Glioblastoma, business, alpha-2-HS-glycoprotein

الوصف: Surgery followed by chemoradiation and adjuvant chemotherapy is standard of care for patients with a glioblastoma (GBM). Due to its limited benefit, an upfront method to predict dismal outcome would prevent unnecessary toxic treatment. We searched for a predictive blood derived biomarker in a cohort of 55 patients with GBM. Increasing age (HR 1.03, 95 % CI 1.01–1.06), and postoperative tumor residue (HR 1.07, 95 % CI 1.02–1.15) were independently associated with unfavourable progression free survival (PFS) in these patients. Corticosteroid use before start of chemoradiaton was strongly predictive for outcome (HR 3.26, 95 % CI 1.67–6.39) with a mean PFS and OS in patients using corticosteroids of 7.3 and 14.6 months, versus 16.1 and 21.6 months in patients not using corticosteroids (p = 0.0005, p

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المؤلفون: Changgeng Ruan, Xiaojin Wu, Depei Wu, Zhaoyue Wang, Lili Zhou, Aining Sun, Li-li Zhu, Xiaoxu Lu, Yue Han, Yongya Ren, Luping Hu, Xiaohui Hu

المصدر: Annals of Hematology; Vol 90
Annals of Hematology

مصطلحات موضوعية: Male, Time Factors, medicine.medical_treatment, Graft vs Host Disease, Hematopoietic stem cell transplantation, 030204 cardiovascular system & hematology, Tissue plasminogen activator, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Prospective Studies, Child, Plasminogen activator inhibitor-1 (PAI-1), Hematology, medicine.diagnostic_test, Hematopoietic Stem Cell Transplantation, General Medicine, Middle Aged, 3. Good health, Protein C (PC), surgical procedures, operative, 030220 oncology & carcinogenesis, Plasminogen activator inhibitor-1, Tissue Plasminogen Activator, Original Article, Female, Thrombotic complication, medicine.drug, Partial thromboplastin time, Adult, medicine.medical_specialty, Adolescent, Opportunistic Infections, Diagnosis, Differential, 03 medical and health sciences, Young Adult, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Transplantation, Homologous, Transplantation-related complications (TRCs), Prothrombin time, Hemostasis, business.industry, Fibrinogen, Thrombosis, Transplantation, Early Diagnosis, chemistry, Immunology, Hematopoietic stem cell transplantation (HSCT), business, Protein C

الوصف: Thrombotic events are common and potentially fatal complications in patients receiving hematopoietic stem cell transplantation (HSCT). Early diagnosis is crucial but remains controversial. In this study, we investigated the early alterations of hemostatic parameters in allogeneic HSCT recipients and determined their potential diagnostic values in transplantation-related thrombotic complications and other post-HSCT events. Results from 107 patients with allogeneic HSCT showed higher levels of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and tissue-plasminogen activator (t-PA) and a lower level of plasma protein C after transplantation. No change was found for prothrombin time, antithrombin III, d-dimer, and activated partial thromboplastin time following HSCT. Transplantation-related complications (TRCs) in HSCT patients were defined as thrombotic (n = 8), acute graft-versus-host disease (aGVHD, n = 45), and infectious (n = 38). All patients with TRCs, especially the patients with thrombotic complications, presented significant increases in the mean and maximum levels of PAI-1 during the observation period. Similarly, a high maximum t-PA level was found in the thrombotic group. In contrast, apparent lower levels of mean and minimum protein C were observed in the TRC patients, especially in the aGVHD group. Therefore, the hemostatic imbalance in the early phase of HSCT, reflecting prothrombotic state and endothelial injury due to the conditioning therapy or TRCs, might be useful in the differential diagnosis of the thrombotic complication from other TRCs.

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المؤلفون: Margriet S. Westerterp-Plantenga, Astrid J. Smeets

المساهمون: Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome

المصدر: European Journal of Nutrition
European Journal of Clinical Nutrition, 48(4), 229-234. Nature Publishing Group

مصطلحات موضوعية: Adult, Male, Acute effects, medicine.medical_specialty, Adolescent, media_common.quotation_subject, education, Medicine (miscellaneous), Satiety Response, Young Adult, chemistry.chemical_compound, Oxygen Consumption, Glucagon-Like Peptide 1, Internal medicine, medicine, Humans, Peptide YY, Obesity, Red pepper, General Psychology, media_common, Cross-Over Studies, Nutrition and Dietetics, Chemistry, Postprandial, digestive, oral, and skin physiology, food and beverages, Substrate (chemistry), Appetite, Thermogenesis, Original Contribution, Middle Aged, Postprandial Period, Glucagon-like peptide-1, Ghrelin, Endocrinology, Capsaicin, Area Under Curve, Biophysics, Female, Energy Metabolism, hormones, hormone substitutes, and hormone antagonists, Hormone

الوصف: BACKGROUND: Addition of capsaicin to the diet has been shown to increase satiety and thermogenesis. The effects of capsaicin on ghrelin, peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), in relation to changes in hunger and satiety are unknown. AIM: To test the acute effects of a lunch containing capsaicin on gut derived hormones (GLP-1, ghrelin, and PYY), energy expenditure (EE), substrate oxidation and satiety at lunch in the postprandial state. METHODS: Thirty subjects (age: 31 +/- 14 years, BMI: 23.8 +/- 2.8 kg/m(2)) were studied twice in a crossover design. After 30 min resting on a bed, resting metabolic rate was measured by a ventilated hood system. Subsequently lunch (35% of daily energy intake) was served. The two lunch conditions were: (1) lunch without capsaicin and (2) lunch with capsaicin (CAPS). The macronutrient composition (energy percentage) of the lunches was 60% carbohydrates, 10% protein and 30% fat. During 3 h after the lunch diet-induced thermogenesis was measured. Furthermore, anchored 100 mm visual analogue scales on the appetite profile were collected (t = 0, 30, 60, 120, 150, 180 and 240) and blood samples were taken for analysis of GLP-1, PYY, and ghrelin concentrations (t = 0, 45, 60, 120, and 180). RESULTS: Satiety and EE were not different after CAPS lunch as compared to the control lunch. Fifteen minutes after lunch CAPS lunch increased GLP-1 (p < 0.05) and tended to decrease ghrelin (p = 0.07) as compared to the control lunch. PYY responses were not different between the CAPS lunch and the control lunch. CONCLUSIONS: An acute lunch containing capsaicin had no effect on satiety, EE, and PYY, but increased GLP-1 and tended to decrease ghrelin.

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