Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts
| العنوان: | Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts |
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| المؤلفون: | Tiphaine Martin, Barbara Thorand, Alex J. MacGregor, Aedin Cassidy, Robert P. Mohney, Cristina Menni, Tess Pallister, Gabi Kastenmüller, Andres Metspalu, Christian Gieger, Amy Jennings, Tim D. Spector, Elisabeth Altmaier, Toomas Haller |
| المصدر: | European Journal of Nutrition Pallister, T, Haller, T, Thorand, B, Altmaier, E, Cassidy, A, Martin, T, Jennings, A, Mohney, R P, Gieger, C, MacGregor, A, Kastenmüller, G, Metspalu, A, Spector, T D & Menni, C 2017, ' Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts ', European Journal of Nutrition, vol. 56, no. 7, pp. 2379–2391 . https://doi.org/10.1007/s00394-016-1278-xTest Eur. J. Nutr. 56, 2379-2391 (2016) Pallister, T, Haller, T, Thorand, B, Altmaier, E, Cassidy, A, Martin, T, Jennings, A, Mohney, R P, Gieger, C, MacGregor, A, Kastenmüller, G, Metspalu, A, Spector, T D & Menni, C 2016, ' Metabolites of milk intake : a metabolomic approach in UK twins with findings replicated in two European cohorts ', EUROPEAN JOURNAL OF NUTRITION, pp. 1-13 . https://doi.org/10.1007/s00394-016-1278-xTest |
| بيانات النشر: | Springer Nature |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Metabolite, Twins, Physiology, Medicine (miscellaneous), Urine, Bioinformatics, Body Mass Index, Cohort Studies, chemistry.chemical_compound, Surveys and Questionnaires, Epidemiology, Micronutrients, 2. Zero hunger, Nutrition and Dietetics, Original Contribution, Middle Aged, Micronutrient, Milk, Cohort, Metabolome, Female, Dietary Proteins, Cohort study, Adult, medicine.medical_specialty, Models, Biological, Sensitivity and Specificity, 03 medical and health sciences, Young Adult, Journal Article, medicine, Dietary Carbohydrates, Valerates, Animals, Humans, Metabolomics, Biomarkers, Nutrition, Uridine, Aged, 030109 nutrition & dietetics, business.industry, Dietary Fats, United Kingdom, Diet, 030104 developmental biology, Nutrition Assessment, chemistry, business, Body mass index |
| الوصف: | PURPOSE: Milk provides a significant source of calcium, protein, vitamins and other minerals to Western populations throughout life. Due to its widespread use, the metabolic and health impact of milk consumption warrants further investigation and biomarkers would aid epidemiological studies. METHODS: Milk intake assessed by a validated food frequency questionnaire was analyzed against fasting blood metabolomic profiles from two metabolomic platforms in females from the TwinsUK cohort (n=3559). The top metabolites were then replicated in two independent populations (EGCUT, n=1109 and KORA, n=1593), and the results from all cohorts were meta-analyzed. RESULTS: Four metabolites were significantly associated with milk intake in the TwinsUK cohort after adjustment for multiple testing (P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1436-6207 |
| DOI: | 10.1007/s00394-016-1278-x |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073bca4da585b3526a344901a8513e1aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....073bca4da585b3526a344901a8513e1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14366207 |
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| DOI: | 10.1007/s00394-016-1278-x |