Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

التفاصيل البيبلوغرافية
العنوان: Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
المؤلفون: Charbel Moussa, Robert A. Rissman, Xu Huang, Paul S. Aisen, R. Scott Turner, Jaeil Ahn, Michaeline Hebron
المصدر: Journal of Neuroinflammation. 14(1)
بيانات النشر: Springer Nature
مصطلحات موضوعية: Male, 0301 basic medicine, Chemokine, Neurology, Adaptive Immunity, Resveratrol, Matrix metalloproteinase, MMP9, chemistry.chemical_compound, 0302 clinical medicine, Activities of Daily Living, Stilbenes, Chemokine CCL5, biology, General Neuroscience, Anti-Inflammatory Agents, Non-Steroidal, Interleukin, Acquired immune system, 3. Good health, Matrix Metalloproteinase 9, Cytokines, Encephalitis, Female, Fibroblast Growth Factor 2, medicine.medical_specialty, Immunology, tau Proteins, 03 medical and health sciences, Cellular and Molecular Neuroscience, Double-Blind Method, Alzheimer Disease, Internal medicine, medicine, Humans, Interleukin 4, Amyloid beta-Peptides, business.industry, Peptide Fragments, 030104 developmental biology, Endocrinology, chemistry, biology.protein, Cognition Disorders, Mental Status Schedule, business, 030217 neurology & neurosurgery, Follow-Up Studies
الوصف: Treatment of mild-moderate Alzheimer’s disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores. For this retrospective study, we examined banked CSF and plasma samples from a subset of AD subjects with CSF Aβ42
اللغة: English
تدمد: 1742-2094
DOI: 10.1186/s12974-016-0779-0
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af73d32e739e5d3d3b4a29e6a52190eTest
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....6af73d32e739e5d3d3b4a29e6a52190e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17422094
DOI:10.1186/s12974-016-0779-0