Lesbian, gay, and bisexual (LGB) persons require cultural humility and informed health care from their healthcare providers. Providers need to understand the distinct differences and intersections of each sexual identity and be aware of the health disparities characteristic of this population. Providers should become knowledgeable of appropriate questions to ask regarding the patient’s sexual identity, relationships, and sexual behavior during the assessment stage, and should concurrently consider how their own understanding, biases, and stereotypes can affect and/or guide diagnosis and treatment. Although the past several decades have witnessed greater acceptance of LGB globally, and more so in Western cultures, providers need to continue to build knowledge and awareness regarding the needs and health disparities of the LGB community.