An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)
| العنوان: | An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD) |
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| المؤلفون: | Alessandro Comi, Paola Cianfrone, Maria Capria, Michele Andreucci, Silvia Corrado, Mariadelina Simeoni, Francesca Deodato, Michele Provenzano, Arturo Pujia, Tiziana Montalcini, Ludovico Abenavoli, Giorgio Fuiano, Annamaria Cerantonio, Massimo Cocchi, Emanuela Libri, Maria Lucia Citraro |
| المساهمون: | Simeoni, M., Citraro, M. L., Deodato, F., Provenzano, M., Capria, M., Comi, A., Libri, E., Andreucci, M., Puja, A., Abenavoli, L., Cocchi, M., Fuiano, G. |
| المصدر: | European Journal of Nutrition |
| بيانات النشر: | Springer Berlin Heidelberg, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Placebo-controlled study, Medicine (miscellaneous), 030209 endocrinology & metabolism, Gut microbiota, Probiotic, 03 medical and health sciences, 0302 clinical medicine, Blood serum, Clinical Protocols, Internal medicine, Chronic kidney disease, medicine, Humans, Renal Insufficiency, Stage (cooking), Uremia, Protocol (science), 030109 nutrition & dietetics, Nutrition and Dietetics, biology, business.industry, Probiotics, C-reactive protein, Correction, Original Contribution, Middle Aged, medicine.disease, Gastrointestinal Microbiome, Dysbiosi, Treatment Outcome, Blood chemistry, biology.protein, Dysbiosis, Female, business, Cohort study |
| الوصف: | Purpose: Gut dysbiosis has been described in advanced, but not in initial stages of CKD. Considering the relevant impact of gut dysbiosis on renal and cardiovascular risk, its diagnosis and treatment are clinically relevant. Methods: We designed, open-label, placebo-controlled intervention study (ProbiotiCKD) to evaluate gut microbiota metabolism in a cohort of KDIGO CKD patients (n = 28) at baseline and after a randomly assigned treatment with probiotics or placebo. Gut microbiota status was evaluated on:. Results: Basal mean fecal Lactobacillales and Bifidobacteria concentrations were abnormally low in both groups, while urinary indican and 3-MI levels were, indicating a mixed (fermentative and putrefactive) dysbiosis. After treatment, mean fecal Lactobacillales and Bifidobacteria concentrations were increased, only in the probiotics group (p < 0.001). Conversely, mean urinary indican and 3-MI levels only in the group treated with probiotics (p < 0.001). Compared to placebo group, significant improvements of C-reactive protein (p < 0.001), iron (p < 0.001), ferritin (p < 0.001), transferrin saturation (p < 0.001), β2-microglobulin (p < 0.001), serum iPTH and serum calcium were observed only in the probiotics group. Conclusions: ProbiotiCKD is the first intervention study demonstrating that an intestinal mixed dysbiosis is present even in early CKD stage and can be effectively corrected by the novel mode of administration of high-quality probiotics with improvement of inflammatory indices, iron status and iPTH stabilization. |
| اللغة: | English |
| تدمد: | 1436-6215 1436-6207 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a3d939950c2c3ac97ac0c3f033c0cfTest http://europepmc.org/articles/PMC6647244Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1a3d939950c2c3ac97ac0c3f033c0cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14366215 14366207 |
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