Endocrine-disrupting chemicals and risk of diabetes: an evidence-based review
| العنوان: | Endocrine-disrupting chemicals and risk of diabetes: an evidence-based review |
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| المؤلفون: | P. Monica Lind, Lars Lind |
| المصدر: | Diabetologia |
| بيانات النشر: | Springer Berlin Heidelberg, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Dichlorodiphenyl Dichloroethylene, Physiology, 030209 endocrinology & metabolism, Review, EDCs, 010501 environmental sciences, Endocrinology and Diabetes, Endocrine Disruptors, 01 natural sciences, DDT, 03 medical and health sciences, Animal data, chemistry.chemical_compound, 0302 clinical medicine, Bisphenol A, Phenols, Diabetes mellitus, Epidemiology, Internal Medicine, medicine, Diabetes Mellitus, Endocrine system, Animals, Humans, Pesticides, Benzhydryl Compounds, Prospective cohort study, 0105 earth and related environmental sciences, Endocrine-disrupting chemicals, business.industry, Diabetes, Glucose Tolerance Test, medicine.disease, Evidence based review, BPA, Dichlorodiphenyldichloroethylene, chemistry, Moderate evidence, Endokrinologi och diabetes, DDE, Chemicals, business |
| الوصف: | The purpose of this study was to review the epidemiological and experimental evidence linking background exposure to a selection of environmental endocrine-disrupting chemicals (EDCs) with diabetes and impaired glucose metabolism. The review summarises the literature on both cross-sectional and prospective studies in humans, as well as experimental in vivo and in vitro studies. The findings were subjected to evidence grading according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification. We found >40 cross-sectional and seven prospective studies regarding EDCs and risk of diabetes. Taken together, there is moderate evidence for a relationship between exposure to dichlorodiphenyldichloroethylene (p,p′-DDE), a metabolite of the pesticide dichlorodiphenyltrichloroethane, and diabetes development. Regarding polychlorinated biphenyls (PCBs), it is likely that the rodent models used are not appropriate, and therefore the evidence is poorer than for p,p′-DDE. For other EDCs, such as bisphenol A, phthalates and perfluorinated chemicals, the evidence is scarce, since very few prospective studies exist. Brominated flame retardants do not seem to be associated with a disturbed glucose tolerance. Thus, evidence is accumulating that EDCs might be involved in diabetes development. Best evidence exists for p,p′-DDE. For other chemicals, both prospective studies and supporting animal data are still lacking. Electronic supplementary material The online version of this article (10.1007/s00125-018-4621-3) contains a slide of the figure for download, which is available to authorised users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2aa06b54306ce3c0e721dfd47c0455Test http://europepmc.org/articles/PMC6445457Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ed2aa06b54306ce3c0e721dfd47c0455 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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