The effect of whole-brain radiation (WBI) and Karnofsky performance status (KPS) on survival of patients receiving stereotactic radiosurgery (SRS) for second brain metastatic event
| العنوان: | The effect of whole-brain radiation (WBI) and Karnofsky performance status (KPS) on survival of patients receiving stereotactic radiosurgery (SRS) for second brain metastatic event |
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| المؤلفون: | John Lamond, A.L. Hanlon, Steven Arrigo, R. Buonocore, L. Brady, D. R. Brown, W. Ding, Jing Feng, M. Stanley, A. Okpaku, Cory Heal, Rachelle Lanciano, Jun Yang |
| المصدر: | Journal of Radiation Oncology |
| بيانات النشر: | Springer Berlin Heidelberg, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, medicine.medical_treatment, CyberKnife, Recursive partitioning, Radiosurgery, Stereotactic radiosurgery (SRS), 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Cyberknife, Internal medicine, Medicine, Survival analysis, Original Research, Performance status, business.industry, Brain metastasis, medicine.disease, Surgery, Radiation therapy, 030220 oncology & carcinogenesis, business, 030217 neurology & neurosurgery, Whole brain irradiation (WBI) |
| الوصف: | Objective The objective of the present study is to analyze prognostic factors affecting survival of patients receiving stereotactic radiosurgery (SRS) for second brain metastatic event (SBME) following initial treatment with whole brain irradiation (WBI), surgical resection, or previous SRS. Methods The 88 patients treated with SRS for SBME at Philadelphia CyberKnife between January 2006 and October 2013 were included in the study group. Cox proportional-hazards regression was used to identify prognostic factors that significantly impacted survival from the time of SRS for SBME. Independent variables considered in survival analysis included primary disease, first brain metastatic event (FBME) treatment type, age, gender, number of brain metastases at SBME, Karnofsky performance status (KPS), recursive partitioning analysis (RPA), and presence of extracranial metastasis. Results The median survival for all patients was 7.31 months. Log-rank comparison of Kaplan-Meier survival curves revealed significant impact by Karnofsky performance status (p = 0.003), RPA class (p = 0.008), age (p = 0.014), and FBME treatment type (p = 0.010). Median survival was longer for patients who had not previously received WBI (14.7 months). Median survival was further increased in patients who had not received previous WBI and demonstrated KPS scores of 70–100 (19.5 months). Patients who received WBI prior to SBME treatment experienced a pronounced decrement in median survival (5.7 months), yet patients in this group who demonstrated strong KPS scores (80–100) experienced significantly increased survival (15.5 months). Conclusions The outcomes of SRS for SBME are most favorable for patients who have not received previous WBI or who have maintained higher performance status despite previous WBI. |
| اللغة: | English |
| تدمد: | 1948-7908 1948-7894 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909692579dda6c0258c647e606710697Test http://europepmc.org/articles/PMC5357253Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....909692579dda6c0258c647e606710697 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19487908 19487894 |
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