Two New Cases of KIR3DP1, KIR2DL4-Negative Genotypes, One of which is also Lacking KIR3DL2
| العنوان: | Two New Cases of KIR3DP1, KIR2DL4-Negative Genotypes, One of which is also Lacking KIR3DL2 |
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| المؤلفون: | Ryszard Grendziak, Natalia Żuk, Anna Havrylyuk, Wanda Niepiekło-Miniewska, Wojciech Witkiewicz, David Senitzer, Valentyna Chopyak, Maciej Kurpisz, Joanna Dubis, Piotr Kuśnierczyk |
| المصدر: | Archivum Immunologiae et Therapiae Experimentalis |
| بيانات النشر: | Springer Basel, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cytotoxicity, Immunologic, Male, Genotype, Pseudogene, Immunology, Killer-cell immunoglobulin-like receptor, Human leukocyte antigen, Biology, HLA-A3 Antigen, KIR2DL4, Deletion, Young Adult, KIR2DL1, Receptors, KIR, Killer cell immunoglobulin-like receptor, Immunology and Allergy, Humans, Receptor, HLA-B27 Antigen, Aged, Genetics, HLA-G Antigens, Polymorphism, Genetic, HLA-A Antigens, Receptors, KIR3DL2, General Medicine, Framework genes, Killer Cells, Natural, Genetics, Population, CpG site, KIR3DL2, Receptors, KIR2DL4, Original Article, Poland, Ukraine, Pseudogenes, Protein Binding |
| الوصف: | The killer immunoglobulin-like receptor (KIR) genes KIR2DL4, KIR3DL2, and KIR3DP1 are present in virtually all humans. KIR2DL4 encodes a receptor present on uterine and decidual natural killer (NK) cells and some peripheral blood NK cells. Its only known ligand is the human leukocyte antigen-G molecule expressed on extravillous trophoblasts, and on tissues in some diseases. KIR3DL2 binds HLA-A*03 and HLA-A*11 as well as HLA-B*27 dimers, and microbial CpG DNA. KIR3DP1 is a pseudogene. During our immunogenetic studies we found two individuals, one from Lower Silesia district in Poland, and another from Western Ukraine, who were reproducibly negative for KIR2DL4 and KIR3DP1 genes, using three different PCR systems. Both individuals displayed very similar genotypes, possessing only KIR3DL3, KIR2DL3, KIR2DP1, KIR2DS1, and probably a rare variant of KIR2DL1. The Pole had also KIR3DL2, which the Ukrainian was apparently lacking. The Lower Silesia has been populated after the Second World War by a remarkable percentage with displaced people from Western Ukraine, which might contribute to genetic similarity of the two individuals described here. |
| اللغة: | English |
| تدمد: | 1661-4917 0004-069X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9aa201e770486835228f716c63a05aTest http://europepmc.org/articles/PMC4164834Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd9aa201e770486835228f716c63a05a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16614917 0004069X |
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