دورية أكاديمية
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD
| العنوان: | CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD |
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| المؤلفون: | Liguori C., Paoletti F. P., Placidi F., Ruffini R., Sancesario G. M., Eusebi P., Mercuri N. B., Parnetti L. |
| المساهمون: | Liguori, C, Paoletti, Fp, Placidi, F, Ruffini, R, Sancesario, Gm, Eusebi, P, Mercuri, Nb, Parnetti, L |
| بيانات النشر: | SPRINGER |
| سنة النشر: | 2019 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Biomarker, CSF, Idiopathic RBD, Neurodegeneration, Synucleinopathy, Aged, Cognitive Dysfunction, Disease Progression, Early Diagnosi, Female, Human, Male, Middle Aged, Parkinson Disease, REM Sleep Behavior Disorder, Synucleinopathie, alpha-Synuclein, Settore MED/26 - NEUROLOGIA |
| الوصف: | Purpose of ReviewIdiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarce data are present in literature about the predictive role of cerebrospinal fluid (CSF) biomarkers. In this review, we focus on CSF biomarkers in patients with both iRBD and RBD associated with synucleinopathies to explore their potential predictive power.Recent FindingsRecent studies revealed that CSF -synuclein levels are higher in Parkinson's disease (PD) patients with RBD compared to those without RBD, even if -synuclein does not seem to predict conversion of iRBD into PD. In the Parkinson Progression Marker Initiative (PPMI) cohort, early PD patients with RBD show lower CSF A(42) levels, which predict faster cognitive decline. CSF prion protein and inflammatory biomarkers have been also investigated in RBD and synucleinopathies with controversial results.SummaryA variety of CSF biomarkers are promising candidate for predicting iRBD conversion into synucleinopathies. Further studies are needed in iRBD patients followed for several years in order to observe the phenoconversion in synucleinopathies and to elucidate the possible role of CSF biomarkers as predictive biomarkers of conversion. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30637520; info:eu-repo/semantics/altIdentifier/wos/WOS:000455599900001; volume:19; issue:2; firstpage:3; journal:CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS; http://hdl.handle.net/2108/228755Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85059878579 |
| DOI: | 10.1007/s11910-019-0918-y |
| الإتاحة: | https://doi.org/10.1007/s11910-019-0918-yTest http://hdl.handle.net/2108/228755Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3D18D7F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11910-019-0918-y |
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