دورية أكاديمية
Two predominant molecular subtypes of spinal meningioma: thoracic NF2‑mutant tumors strongly associated with female sex, and cervical AKT1‑mutant tumors originating ventral to the spinal cord
| العنوان: | Two predominant molecular subtypes of spinal meningioma: thoracic NF2‑mutant tumors strongly associated with female sex, and cervical AKT1‑mutant tumors originating ventral to the spinal cord |
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| المؤلفون: | Hua, Lingyang, Alkhatib, Majd, Podlesek, Dino, Günther, Leila, Pinzer, Thomas, Meinhardt, Matthias, Zeugner, Silke, Herold, Sylvia, Cahill, Daniel P., Brastianos, Priscilla K., Williams, Erik A., Clark, Victoria E., Shankar, Ganesh M., Wakimoto, Hiroaki, Ren, Leihao, Chen, Jiawei, Gong, Ye, Schackert, Gabriele, Juratli, Tareq A. |
| حالة النشر: | publishedVersion |
| بيانات النشر: | Springer, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Original Material: | urn:nbn:de:bsz:14-qucosa2-910475 |
| مصطلحات موضوعية: | thoracic NF2‑mutant tumors, cervical AKT1‑mutant tumors, Spinal meningiomas (SM), primary meningiomas, spinal intradural tumors, thorakale NF2-mutierte Tumoren, zervikale AKT1-mutierte Tumoren, spinale Meningeome (SM), primäre Meningeome, spinale intradurale Tumore, info:eu-repo/classification/ddc/610, ddc:610 |
| الوصف: | Spinal meningiomas (SM) comprise 5–10% of primary meningiomas and up to 30% of spinal intradural tumors. SMs are usually sporadic, but rarely, they can develop in association with genetic diseases like neurofibromatosis type 2 or schwannomatosis [2, 4, 6]. While the mutational landscape of intracranial meningiomas has been extensively studied [3, 5, 11, 14], our understanding of the molecular profile of SM remains incomplete. To date, genomic studies in SMs have been underpowered to make significant conclusions about the correlations between main genomic driver alterations and clinical features of these tumors. Here, we sought to assess the mutational profile of WHO grade 1 SM and to investigate the clinical characteristics that correlate with the genomic status. |
| Original Identifier: | oai:qucosa:de:qucosa:91047 |
| نوع الوثيقة: | Article |
| اللغة: | English |
| تدمد: | 1432-0533 |
| DOI: | 10.1007/s00401-022-02474-9 |
| الإتاحة: | https://tud.qucosa.de/id/qucosa%3A91047Test https://tud.qucosa.de/api/qucosa%3A91047/attachment/ATT-0Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.DRESDEN.oai.qucosa.de.qucosa.91047 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| تدمد: | 14320533 |
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| DOI: | 10.1007/s00401-022-02474-9 |