المؤلفون: Wu, Y, Chu, L, Yang, H, Wang, W, Deng, H

المساهمون: Department of Applied Social Sciences

مصطلحات موضوعية: Optimal time-lag, Salivary biomarkers, LC-MS/MS, Testosterone, Transdermal administration

الوصف: 202305 bcww ; Not applicable ; Others ; National Natural Science Foundation of China (31800952 and 31600923) ; Published ; 12 months

العلاقة: http://hdl.handle.net/10397/98463Test; 297; 306; 73; 4-5; WOS:000973861100001; a2005; 46302

الإتاحة: https://doi.org/10.1007/s12031-023-02118-xTest
http://hdl.handle.net/10397/98463Test

المؤلفون: Corrêa, Adriana C, Machado, Carla J, Carneiro, Sueli C S

المصدر: Arch Dermatol Res ; ISSN:1432-069X ; Volume:316 ; Issue:6

مصطلحات موضوعية: Androgenetic alopecia, Female Pattern Hair Loss, Medicine microinfusion into the skin (MMP®), Minoxidil, Scalp microinfusion, Transdermal drug delivery

الوصف: Female Pattern Hair Loss (FPHL) is a common form of non-scaring hair loss that occurs in adult women. Although several treatments have already been proposed for FPHL, only Topical Minoxidil accumulated an adequate level of evidence. This study aimed to evaluate the therapeutic response of MMP® (intradermal infiltration) of Minoxidil formulation in the frontal-parietal-vertex regions compared with the gold-standard home administration of Minoxidil 5% Capillary Solution. This self-controlled comparative study evaluated 16 FPHL patients, without treatment for at least 6 months, confirmed by trichoscopy with TrichoLAB® software. They received 4 monthly sessions of MMP® with Minoxidil 0,5% on the right side of the scalp (frontal-parietal-vertex areas), followed by occlusion with plastic film for 12 h and prescription of Minoxidil 5% Solution for home use once a day, on both scalp sides, starting 72 h after the procedure. The reassessment trichoscopy was 6 weeks after the last session and they answered a "self-assessment" questionnaire. Treated scalp areas were compared and showed both treatments, in general, were effective, with no difference between them. If they were analyzed separately by treated areas, there were signs of better response in the parietal-vertex regions with treatment by MMP® with Minoxidil, while clinical treatment indicated a better response in the other regions. When patients were divided into more and less advanced cases, a better response in parietal-vertex regions treated by MMP® with Minoxidil in less advanced patients was confirmed. MMP® with Minoxidil showed a better response in the parietal-vertex regions in less advanced FPHL patients. It represents yet another resource to improve quality of life of these suffering patients.

العلاقة: https://doi.org/10.1007/s00403-024-03053-6Test; https://pubmed.ncbi.nlm.nih.gov/38822940Test

الإتاحة: https://doi.org/10.1007/s00403-024-03053-6Test
https://pubmed.ncbi.nlm.nih.gov/38822940Test

المؤلفون: Schlich, Michele, Musazzi, Umberto M., Campani, Virginia, Biondi, Marco, Franzé, Silvia, Lai, Francesco, De Rosa, Giuseppe, Sinico, Chiara, Cilurzo, Francesco

المساهمون: M. Schlich, U.M. Musazzi, V. Campani, M. Biondi, S. Franzé, F. Lai, G. De Rosa, C. Sinico, F. Cilurzo

مصطلحات موضوعية: Transdermal, Regulatory science, Liposome, Skin penetration, Drug release, Franz cell, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo

الوصف: The skin is the absorption site for drug substances intended to treat loco-regional diseases, although its barrier properties limit the permeation of drug molecules. The growing knowledge of the skin structure and its physiology have supported the design of innovative nanosystems (e.g. liposomal systems) to improve the absorption of poorly skin-permeable drugs. However, despite the dozens of clinical trials started, few topically applied liposomal systems have been authorized both in the EU and the USA. Indeed, the intrinsic complexity of the topically applied liposomal systems, the higher production costs, the lack of standardized methods and the more stringent guidelines for assessing their benefit/risk balance can be seen as causes of such inefficient translation. The present work aimed to provide an overview of the physicochemical and biopharmaceutical characterization methods that can be applied to topical liposomal systems intended to be marketed as medicinal products, and the current regulatory provisions. The discussion highlights how such methodologies can be relevant for defining the critical quality attributes of the final product, and they can be usefully applied based on the phase of the life cycle of a liposomal product: to guide the formulation studies in the early stages of development, to rationally design preclinical and clinical trials, to support the pharmaceutical quality control system and to sustain post-marketing variations. The provided information can help define harmonized quality standards able to overcome the case-by-case approach currently applied by regulatory agencies in assessing the benefit/risk of the topically applied liposomal systems.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34755281; info:eu-repo/semantics/altIdentifier/wos/WOS:000716306200001; firstpage:1; lastpage:18; numberofpages:18; journal:DRUG DELIVERY AND TRANSLATIONAL RESEARCH; http://hdl.handle.net/2434/884253Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118684161

الإتاحة: https://doi.org/10.1007/s13346-021-01089-zTest
http://hdl.handle.net/2434/884253Test

المؤلفون: Nnamani, Petra O, Ugwu, Agatha A, Nnadi, Ogechukwu H, Kenechukwu, Franklin C, Ofokansi, Kenneth C, Attama, Anthony A, Lehr, Claus-Michael

المساهمون: HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

المصدر: Drug delivery and translational research ; United States

مصطلحات موضوعية: Artemether, Ex vivo skin permeation, Malaria, Nanogel, Nanostructured lipid carrier, Transdermal

الوصف: rtemether (ART) is second to artesunate in being the most widely used derivatives of artemisinin in combination therapy of malaria. Nanostructured lipid carrier (NLC) formulations were prepared following our previous report using optimized ART concentration of 0.25 g dissolved in 5% w/v mixture of solid (Gelucire 43/01 and Phospholipon 85G) and liquid (Transcutol) lipids at 90 °C. An aqueous surfactant phase at 90 °C was added (dropwise) under magnetic stirring (1000 rpm) for 5 min. The pre-emulsion was speedily homogenized at 28,000 rpm for 15 min and further probe sonicated at 60% amplitude (15 min). Resultant sample was cooled at room temperature and frozen at - 80 °C prior to lyophilization. The freeze-dried sample was used for solid-state characterization as well as in the formulation of transdermal nanogels using three polymers (Carbopol 971P, Poloxamer 407, and Prosopis africana peel powder) to embed the ART-NLC, using ethanol as a penetration enhancer. Transdermal ART-nanogels were characterized accordingly (physical examination, pH, drug content, rheology, spreadability, stability, particle size and morphology, skin irritation, in vitro and ex vivo skin permeation, and analysis of permeation data), P < 0.05. Results indicated that ART nanogels showed good encapsulation, drug release, pH-dependent swelling, stability, and tolerability. Overall, ART nanogels prepared from Poloxamer 407 showed the most desirable drug permeation, pH, swellability, spreadability, viscosity, and transdermal antiplasmodial properties superior to PAPP-ANG > C971P-ANG. A two-patch/week concurrent application of the studied nanogels could offer 100% cure of malaria as a lower-dose (50 mg ART) patient-friendly regimen devoid of the drug's many side effects.

العلاقة: Drug Deliv Transl Res. 2021 Mar 19. doi:10.1007/s13346-021-00951-4. Epub ahead of print.; http://hdl.handle.net/10033/622862Test; Drug delivery and translational research

الإتاحة: https://doi.org/10.1007/s13346-021-00951-4Test
http://hdl.handle.net/10033/622862Test

المساهمون: Jee-Hyun Park, Cheong Bi Kim, Hyun-Ji Lee, Joo Young Roh, Jae Myun Lee, Hee Joo Kim, Jung-Hwan Park, Lee, Jae Myun

مصطلحات موضوعية: Adult, Erythema / etiology, Female, Humans, Hyaluronic Acid / administration & dosage, Hyaluronic Acid / chemistry, Infrared Rays / adverse effects, Male, Microinjections / instrumentation, Solubility, Transdermal Patch, Clinical study, Dissolving microneedle array patch (MAP), Infrared radiation, Dissolution rate, Transepidermal water loss (TEWL), Erythema, Active evaporating

الوصف: The dissolution rate of a microneedle array patch (MAP) determines how long a MAP must remain attached to the skin (often called "wear time"). In this study, the dissolution rate of a MAP was increased, not by changing the drug formulation but by employing an infrared (IR) device that is widely used for hospital treatment and in-home therapy. A MAP with microneedles 480 mu m in height was prepared using hyaluronic acid (HA). Changes in transepidermal water loss (TEWL), the surface temperature of the skin, and the dissolution rate of the MAP tips with IR irradiation were evaluated on human skin in vivo. Time for recovery from erythema that occurred after MAP attachment and IR irradiation was also evaluated. TEWL increased more than fourfold with IR irradiation. Water that evaporated as a result of IR irradiation was trapped in the skin layer by the patch, resulting in the increased dissolution rate of the MAP tips. After 10 min of IR irradiation, the height of the dissolving tips compared with their initial height increased from 41 to 56%, and the dissolved volume of the tips compared with their initial volume increased from 7 to 18%. During the 10 min of irradiation, the skin surface temperature rose from 32 to 40 degrees C. Erythema occurred in the early stage of treatment with IR irradiation and MAP attachment, but it abated within 2 h after removal of the MAP and cessation of IR irradiation. Through this study, it was possible to shorten the administration time of MAPs by using an IR device that could be easily accessed. This method can be applied to various types of MAPs in order to reduce the time that the MAPs must remain attached to the skin without changing the drug formulation. The increase in dissolution rate of dissolving microneedle array patch (MAP) as a result of infrared radiation. a Water-soluble tips of MAP dissolved in water in skin without infrared irradiation. Dotted line indicates the initial dissolving microneedles. b Water in skin and subcutaneous layer evaporated actively with infrared ...

العلاقة: DRUG DELIVERY AND TRANSLATIONAL RESEARCH; J04099; OAK-2022-03681; https://ir.ymlib.yonsei.ac.kr/handle/22282913/190071Test; https://linkTest.springer.com/article/10.1007/s13346-020-00710-x; T9992020293; DRUG DELIVERY AND TRANSLATIONAL RESEARCH, Vol.10(3) : 791-800, 2020-06

الإتاحة: https://doi.org/10.1007/s13346-020-00710-xTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/190071Test

المؤلفون: Álvarez Figueroa, María Javiera, Narváez Araya, Daniela, Armijo Escalona, Nicolás, Carrasco Flores, Eduardo, González Aramundiz, José Vicente

المصدر: Pharmaceutical Research

مصطلحات موضوعية: Chitosan-nanocapsules, Compritol 888 ATO®, Imiquimod, Raman microscopy, Transdermal

الوصف: Purpose Design imiquimod-loaded chitosan nanocapsules for transdermal delivery and evaluate the depth of imiquimod transdermal absorption as well as the kinetics of this absorption using Raman Microscopy, an innovative strategy to evaluate transdermal absorption. This nanovehicle included Compritol 888ATO (R), a novel excipient for formulating nanosystems whose administration through the skin has not been studied until now. Methods Nanocapsules were made by solvent displacement method and their physicochemical properties was measured by DLS and laser-Doppler. For transdermal experiments, newborn pig skin was used. The Raman spectra were obtained using a laser excitation source at 532 nm and a 20/50X oil immersion objective. Results The designed nanocapsules, presented nanometric size (180 nm), a polydispersity index <0.2 and a zeta potential +17. The controlled release effect of Compritol was observed, with the finding that half of the drug was released at 24 h in comparison with control (p < 0.05). It was verified through Raman microscopy that imiquimod transdermal penetration is dynamic, the nanocapsules take around 50 min to penetrate the stratum corneum and 24 h after transdermal administration, the drug was in the inner layers of the skin. ; Fondo Nacional de Desarrollo Científico y Tecnológico de Chile FONDECYT 1201482 Programa de Equipamiento Científico y Tecnológico FONDEQUIP EQM120021 FONDEQUIP EQM130032

وصف الملف: application/pdf

العلاقة: Pharm Res (2020) 37: 195; https://repositorio.uchile.cl/handle/2250/178688Test

الإتاحة: https://doi.org/10.1007/s11095-020-02925-6Test
https://repositorio.uchile.cl/handle/2250/178688Test

المؤلفون: Adhikary, Sourav, Al Hoque, Ashique, Ray, Manisheeta, Paul, Swastik, Hossain, Akbar, Goswami, Subrata, Dey, Rajib

المصدر: Appl Biochem Biotechnol ; ISSN:1559-0291 ; Volume:195 ; Issue:8

مصطلحات موضوعية: Analgesic activity, Silica nanoparticles, Skin permeation, Sustained release, Transdermal patch

الوصف: An effort was made to administer paracetamol drug through transdermal patch, as no such formulation of this drug has been developed yet. The primary cause for the lack of such formulations is paracetamol's poor aqueous solubility. As a result, the current research concentrated on preparing nanomedicines, or drug-loaded nanoparticles, for delivery via transdermal formulations. Nanoparticles can improve the solubility of weakly aqueous soluble or even aqueous insoluble drugs by changing the crystalline structure of loaded medicines to an amorphous state and serving as drug permeation boosters. Silica nanoparticles (SNPs) were synthesized through sol-gel technique to achieve the aforementioned goal. DLS data revealed that the average particle size was around 100-200 nm, which was sufficient to penetrate the skin barrier. XRD analysis showed that the SNPs were amorphous, and the drug molecules lost their crystallinity after encapsulation into the nanoparticles, causing the enhancement of dissolution of drug molecules in physiological pH (pH-7.4). Different kinetic models were employed for the ex vivo dissolution data to evaluate the suitable kinetic model followed by the drug release in both burst and sustained phase. In vivo analgesic study was executed on mice applying each of the transdermal formulations to examine the performances of the patches.

العلاقة: https://doi.org/10.1007/s12010-023-04576-wTest; https://pubmed.ncbi.nlm.nih.gov/37273095Test

الإتاحة: https://doi.org/10.1007/s12010-023-04576-wTest
https://pubmed.ncbi.nlm.nih.gov/37273095Test

المؤلفون: Alba-Molina, David, Giner-Casares, Juan J., Cano, Manuel

المصدر: Topics in Current Chemistry 378, 8 (2020)

مصطلحات موضوعية: Plasmonic nanoparticles, Transdermal drug delivery, Bioconjugated nanomaterials, Skin penetration, Gold and silver nanoparticles

الوصف: Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic nanomaterials for different biomedical applications. Plasmonic NPs have excellent biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities. Herein, we review recently reported bioconjugated plasmonic NPs using different chemical approaches and loading cargoes (such as drugs, genes, and proteins) for enhancement of transdermal delivery across biological tissues. The main aim is to understand the interaction of the complex skin structure with biomimetic plasmonic NPs. This knowledge is not only important in enhancing transdermal delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetics, sunscreen formulations and any other mass-usage consumable that contains plasmonic NPs.

وصف الملف: application/pdf

العلاقة: https://doi.org/10.1007/s41061-019-0273-0Test; Gobierno de España. CTQ2017-83961-R; Gobierno de España. CTQ2017-92264-EXP; Gobierno de España. RyC-2014-14956; http://hdl.handle.net/10396/21023Test

الإتاحة: https://doi.org/10.1007/s41061-019-0273-0Test
http://hdl.handle.net/10396/21023Test

المؤلفون: Tomohiro Aoki, Kenji Sugibayashi, Shoko Itakura, Masato Saito, Ichiro Hijikuro, Takamasa Suzuki, Hiroaki Todo

المصدر: Pharmaceutical Research. 38(2):289-299

مصطلحات موضوعية: Glycerol, Skin Absorption, Transdermal Patch, Pharmaceutical Science, skin permeation, Human skin, 02 engineering and technology, Administration, Cutaneous, 030226 pharmacology & pharmacy, Permeability, self-assembling lipid, hydrophilic drug, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Glycerol ester of wood rosin, Adhesives, drug-in-adhesive patch, Keratin, skin permeation enhancer, Stratum corneum, medicine, Animals, Humans, Pharmacology (medical), Barrier function, Pharmacology, chemistry.chemical_classification, Chromatography, integumentary system, Chemistry, Organic Chemistry, Penetration (firestop), Permeation, 021001 nanoscience & nanotechnology, Liquid Crystals, Rats, medicine.anatomical_structure, Molecular Medicine, Fluorescein, Adhesive, Epidermis, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions, Biotechnology

الوصف: Purpose: Penetration enhancers are necessary to overcome a formidable barrier function of the stratum corneum in the development of topical formulations. Recently, non-lamella liquid crystal (NLLC)-forming lipids such as glycerol monooleate and phytantriol (PHY) are gaining increasing attention as a novel skin permeation enhancer. In the present study, fluorescein sodium (FL-Na) was used as a model hydrophilic drug, and acryl-base pressure-sensitive adhesive (PSA) tape containing NLLC forming lipids, mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE) or PHY, was prepared to enhance drug permeation through the skin.Methods: A PSA patch containing FL-Na was prepared by mixing FL-Na entrapped in NLLC and acrylic polymer. FL permeation through excised hairless rat skin, and also human skin, was investigated. Changes in lipid structure, folding/unfolding state of keratin in the stratum corneum, and penetration of MGE into the stratum corneum were investigated using confocal Raman microscopy.Results: Enhanced FL permeation was observed by the application of a PSA patch containing MGE and PHY. Especially, dramatically enhancement effect was confirmed by 15% of MGE contained formulation. Penetration of MGE provided diminished orthorhombic crystal structure and a peak shift of the aliphatic CH3 vibration of keratin chains toward lower wavenumbers.Conclusion: The present results suggested that the formulation development by adding MGE may be useful for improving the skin permeation of mal-permeable drugs such as hydrophilic drugs.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2a9fbf862ed9d9bf7a4c53b97999cdTest
https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s11095-021-02996-zTest

المؤلفون: Guy, Richard H

المصدر: Drug Deliv Transl Res ; ISSN:2190-3948 ; Volume:14 ; Issue:8

مصطلحات موضوعية: Drug delivery technology, Skin barrier function, Skin penetration enhancement – chemical, Skin penetration enhancement – physical, Topical and transdermal drug delivery, Topical formulations and metamorphosis

الوصف: Drug delivery technology has advanced significantly over >50 years, and has produced remarkable innovation, countless publications and conferences, and generations of talented and creative scientists. However, a critical review of the current state-of-the-art reveals that the translation of clever and sophisticated drug delivery technologies into products, which satisfy important, unmet medical needs and have been approved by the regulatory agencies, has - given the investment made in terms of time and money - been relatively limited. Here, this point of view is illustrated using a case study of technology for drug delivery into and through the skin and aims: to examine the historical development of this field and the current state-of-the-art; to understand why the translation of drug delivery technologies into products that improve clinical outcomes has been quite slow and inefficient; and to suggest how the impact of technology may be increased and the process of concept to approved product accelerated.

العلاقة: https://doi.org/10.1007/s13346-024-01614-wTest; https://pubmed.ncbi.nlm.nih.gov/38837116Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208237Test/

الإتاحة: https://doi.org/10.1007/s13346-024-01614-wTest
https://pubmed.ncbi.nlm.nih.gov/38837116Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208237Test/