المؤلفون: Sioofy-Khojine, Amir-Babak, Richardson, Sarah J., Locke, Jonathan M., Oikarinen, Sami, Nurminen, Noora, Laine, Antti-Pekka, Downes, Kate, Lempainen, Johanna, Todd, John A., Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Morgan, Noel G., Hyöty, Heikki, Peakman, Mark, Eichmann, Martin

المساهمون: HUS Children and Adolescents, Children's Hospital, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism

مصطلحات موضوعية: Autoimmunity, Enterovirus, Genetic risk, IFIH-1, Interferon induced with helicase C domain 1, MDA5, Melanoma differentiation-associated protein 5, Pancreatic islets, rs1990760, Type 1 diabetes, CAPSID PROTEIN VP1, RIG-I, FUNCTION MUTATIONS, HLA GENOTYPES, INFECTION, CHILDREN, RECOGNITION, EXPRESSION, DIAGNOSIS, MELLITUS, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: The study was supported by a centre grant Diabetes - Genes, Autoimmunity and Prevention (D-GAP) from the JDRF (1-2007-1803) to MP, JAT, P. Bingley (University of Bristol), T. Tree (King's College London) and D. Dunger (University of Cambridge), a JDRF Career Development Award (5-CDA-2014-221-A-N) to SJR, a JDRF research grant awarded to the network of Pancreatic Organ Donors - Virus (nPOD-V) consortium (JDRF 25-2012-516), a Medical Research Council project grant (MR/P010695/1) awarded to SJR and NGM, a strategic award to JAT from the JDRF (4-SRA-2017-473-A-N) and the Wellcome Trust (07212/A/15/Z) and by the European Commission (Persistent Virus Infection in Diabetes Network [PEVNET] Frame Programme 7, coordinated by HH, contract number 261441). The virus analyses in Tampere University were additionally funded by grants to HH from the Sigrid Juselius Foundation and the Academy of Finland (grant number 288671). This study also reports independent research supported by the National Institute of Health Research Exeter Clinical Research Facility. Funders were not involved in the design and conduct of the study, the collection, analysis and interpretation of the data, or the preparation, review or approval of the manuscript. As such, the content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.; Sioofy-Khojine , A-B , Richardson , S J , Locke , J M , Oikarinen , S , Nurminen , N , Laine , A-P , Downes , K , Lempainen , J , Todd , J A , Veijola , R , Ilonen , J , Knip , M , Morgan , N G , Hyöty , H , Peakman , M & Eichmann , M 2022 , ' Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage ' , Diabetologia , vol. 65 , no. 10 , pp. 1701-1709 . https://doi.org/10.1007/s00125-022-05753-yTest; d4473333-8fbd-4218-a10a-f80e50209d00; http://hdl.handle.net/10138/348270Test; 000829987300001

الإتاحة: http://hdl.handle.net/10138/348270Test

المؤلفون: Leete, P., Oram, Richard A., McDonald, Timothy J., Shields, Beverley M, Hattersley, Andrew T., Richardson, Sarah J., Morgan, Noel

مصطلحات موضوعية: C-peptide, CD20+ cells, CD8+ cells, Immunophenotype, Insulitis, Islets of Langerhans, Wessex Classification Subject Headings::Endocrinology::Diabetes

وصف الملف: application/pdf

العلاقة: https://doi.org/10.1007/s00125-020-05115-6Test; Leete P et al. Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis. Diabetologia. 2020;63(6):1258-1267. doi:10.1007/s00125-020-05115-6; https://rde.dspace-express.com/handle/11287/621394Test; Diabetologia; PMC7228905

الإتاحة: https://doi.org/10.1007/s00125-020-05115-6Test
https://rde.dspace-express.com/handle/11287/621394Test

المؤلفون: Dunne, Jessica L., Richardson, Sarah J., Atkinson, Mark A., Craig, Maria E., Dahl-Jørgensen, Knut, Flodström-Tullberg, Malin, Hyöty, Heikki, Insel, Richard A., Lernmark, Åke, Lloyd, Richard E., Morgan, Noel G., Pugliese, Alberto

المصدر: Diabetologia; 62(5), pp 744-753 (2019) ; ISSN: 0012-186X

مصطلحات موضوعية: Endocrinology and Diabetes, Infectious Medicine, Antiviral therapy, Autoimmunity, Beta cells, Enterovirus, Pancreas, Prevention, Type 1 diabetes, Vaccine, Virus

العلاقة: https://lup.lub.lu.se/record/36217fce-5457-4b6d-b700-f341b29028c9Test; http://dx.doi.org/10.1007/s00125-019-4811-7Test; scopus:85060630556; pmid:30675626

الإتاحة: https://doi.org/10.1007/s00125-019-4811-7Test
https://lup.lub.lu.se/record/36217fce-5457-4b6d-b700-f341b29028c9Test

المؤلفون: Leete, Pia, Mallone, Roberto, Richardson, Sarah J., Sosenko, Jay M., Redondo, Maria J., Evans-Molina, Carmella

المساهمون: Medicine, School of Medicine

المصدر: Author

مصطلحات موضوعية: type 1 diabetes, age, C-peptide

وصف الملف: application/pdf

العلاقة: Current Diabetes Reports; Leete, P., Mallone, R., Richardson, S. J., Sosenko, J. M., Redondo, M. J., & Evans-Molina, C. (2018). The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms. Current Diabetes Reports, 18(11), 115. https://doi.org/10.1007/s11892-018-1083-4Test; https://hdl.handle.net/1805/19604Test

الإتاحة: https://hdl.handle.net/1805/19604Test

المؤلفون: Locke Jonathan M., Eichmann Martin, Lempainen Johanna, Nurminen Noora, Peakman Mark, Morgan Noel G., Sioofy-Khojine Amir-Babak, Knip Mikael, Oikarinen Sami, Laine Antti-Pekka, Ilonen Jorma, Hyöty Heikki, Downes Kate, Veijola Riitta, Richardson Sarah J., Todd John A.

المساهمون: tyks, vsshp, tyks, vsshp, biolääketieteen laitos, yhteiset, Institute of Biomedicine, lastentautioppi, Paediatrics and Adolescent Medicine, MediCity, MediCity Research Laboratory, 2607100, 2607313, 2607003

العلاقة: Diabetologia; https://www.utupub.fi/handle/10024/169081Test; https://doi.org/10.1007/s00125-022-05753-yTest; URN:NBN:fi-fe2022091258756

الإتاحة: https://doi.org/10.1007/s00125-022-05753-yTest
https://www.utupub.fi/handle/10024/169081Test

المؤلفون: Willcox, A, Richardson, Sarah J., Bone, AJ, Foulis, Alan K., Morgan, Noel G.

مصطلحات موضوعية: Adolescent, Adult, Capsid Proteins, Cell Proliferation, Child, Diabetes Mellitus, Type 1, Enterovirus, Female, Humans, Immunohistochemistry, Infant, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Ki-67 Antigen, Male, Retrospective Studies, Virus Replication, Young Adult

العلاقة: http://www.ncbi.nlm.nih.gov/pubmed/21597997Test; Vol. 54, pp. 2417 - 2420; http://hdl.handle.net/10871/18088Test; Diabetologia

الإتاحة: https://doi.org/10.1007/s00125-011-2192-7Test
http://hdl.handle.net/10871/18088Test