دورية أكاديمية
Proteomic analysis of diabetes genetic risk scores identifies complement C2 and neuropilin-2 as predictors of type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.
| العنوان: | Proteomic analysis of diabetes genetic risk scores identifies complement C2 and neuropilin-2 as predictors of type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. |
|---|---|
| المؤلفون: | Steffen, Brian T, Tang, Weihong, Lutsey, Pamela L, Demmer, Ryan T, Selvin, Elizabeth, Matsushita, Kunihiro, Morrison, Alanna C, Guan, Weihua, Rooney, Mary R, Norby, Faye L, Pankratz, Nathan, Couper, David, Pankow, James S |
| المصدر: | Diabetologia ; ISSN:1432-0428 ; Volume:66 ; Issue:1 |
| بيانات النشر: | Springer |
| سنة النشر: | 2023 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Beta cell, Diabetes, Genetic risk score, Insulin resistance, Mendelian, Proteomics |
| الوصف: | Genetic predisposition to type 2 diabetes is well-established, and genetic risk scores (GRS) have been developed that capture heritable liabilities for type 2 diabetes phenotypes. However, the proteins through which these genetic variants influence risk have not been thoroughly investigated. This study aimed to identify proteins and pathways through which type 2 diabetes risk variants may influence pathophysiology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s00125-022-05801-7Test; https://pubmed.ncbi.nlm.nih.gov/36194249Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742300Test/ |
| DOI: | 10.1007/s00125-022-05801-7 |
| الإتاحة: | https://doi.org/10.1007/s00125-022-05801-7Test https://pubmed.ncbi.nlm.nih.gov/36194249Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742300Test/ |
| حقوق: | © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
| رقم الانضمام: | edsbas.FB54D090 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00125-022-05801-7 |
|---|