كتاب
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange
| العنوان: | T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange |
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| المؤلفون: | Sipido, Karin R., Acsai, Károly, Antoons, Gudrun, Bito, Virginie, Macquaide, Niall |
| المصدر: | Sipido , K R , Acsai , K , Antoons , G , Bito , V & Macquaide , N 2013 , T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange . in Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications . vol. 961 , Advances in Experimental Medicine and Biology , Springer , pp. 375-383 . https://doi.org/10.1007/978-1-4614-4756-6_32Test |
| بيانات النشر: | Springer |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Animals, Calcium/metabolism, Calcium Channels, L-Type/genetics, Humans, Muscle Proteins/genetics, Myocytes, Cardiac/metabolism, Ryanodine Receptor Calcium Release Channel/genetics, Sarcoplasmic Reticulum/genetics, Sodium/metabolism, Sodium-Calcium Exchanger/genetics |
| الوصف: | The Na(+)/Ca(2+) exchanger (NCX) is a key regulator of intracellular Ca(2+) in cardiac myocytes, predominantly contributing to Ca(2+) removal during the diastolic relaxation process but also modulating excitation-contraction coupling. NCX is preferentially located in the T-tubules and can be close to or within the dyad, where L-type Ca(2+) channels face ryanodine receptors (RyRs), the Ca(2+) release channels of the sarcoplasmic reticulum. However, especially in larger animals, not all RyRs are in dyads or adjacent to T-tubules, and a substantial fraction of Ca(2+) release from the sarcoplasmic reticulum thus occurs at distance from NCX. This chapter deals with the functional consequences of NCX location and how NCX can modulate diastolic and systolic Ca(2+) events. The loss of T-tubules and the effects on RyR function and NCX modulation are explored, as well as quantitative measurement of local Ca(2+) gradients at the level of the dyadic space. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| DOI: | 10.1007/978-1-4614-4756-6_32 |
| الإتاحة: | https://doi.org/10.1007/978-1-4614-4756-6_32Test https://researchonline.gcu.ac.uk/en/publications/70c8c117-38ca-41d7-ab5a-683e51f20786Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.296F18DC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/978-1-4614-4756-6_32 |
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