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Disease-related patterns of in vivo pathology in corticobasal syndrome

التفاصيل البيبلوغرافية
العنوان: Disease-related patterns of in vivo pathology in corticobasal syndrome
المؤلفون: Silvia Paola Caminiti, Davide Martino, Alexander Whittington, Marcello Esposito, Flavia Niccolini, Roberto Erro, Ali Abdul, Heather Wilson, Alzheimer’s Disease Neuroimaging Initiative, Roger N. Gunn, Marios Politis, Eugenii A. Rabiner, Stephanie T. Hirschbichler, Jan Passchier, Gennaro Pagano, Tayyabah Yousaf, Kailash P. Bhatia, Janice L. Holton, Zane Jaunmuktane
المساهمون: Niccolini, F., Wilson, H., Hirschbichler, S., Yousaf, T., Pagano, G., Whittington, A., Caminiti, S. P., Erro, R., Holton, J. L., Jaunmuktane, Z., Esposito, M., Martino, D., Abdul, A., Passchier, J., Rabiner, E. A., Gunn, R. N., Bhatia, K. P., Politis, M.
المصدر: European Journal of Nuclear Medicine and Molecular Imaging
بيانات النشر: Springer, 2018.
سنة النشر: 2018
مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, MILD COGNITIVE IMPAIRMENT, TRACER, Disease, 0302 clinical medicine, Gyrus, Nuclear Medicine and Imaging, BINDING, medicine.diagnostic_test, Radiology, Nuclear Medicine & Medical Imaging, Neurodegenerative Diseases, General Medicine, DEGENERATION, Middle Aged, Corticobasal syndrome, Magnetic Resonance Imaging, White Matter, 3. Good health, ALZHEIMERS-DISEASE, Nuclear Medicine & Medical Imaging, Carboline, medicine.anatomical_structure, MRI, PET, Tau, Radiology, Nuclear Medicine and Imaging, Original Article, Female, Case-Control Studie, Radiology, Life Sciences & Biomedicine, Human, medicine.medical_specialty, 0299 Other Physical Sciences, Posterior parietal cortex, Grey matter, DIAGNOSIS, 03 medical and health sciences, POSITRON-EMISSION-TOMOGRAPHY, In vivo, Fractional anisotropy, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cognitive Dysfunction, F-18-AV-1451, Aged, Kinetic, Science & Technology, Neurodegenerative Disease, business.industry, Brain biopsy, Precentral gyrus, Biological Transport, 1103 Clinical Sciences, PROGRESSIVE SUPRANUCLEAR PALSY, Alzheimer’s Disease Neuroimaging Initiative, Kinetics, 030104 developmental biology, Case-Control Studies, Positron-Emission Tomography, business, 030217 neurology & neurosurgery, Carbolines
الوصف: Purpose To assess disease-related patterns of in vivo pathology in 11 patients with Corticobasal Syndrome (CBS) compared to 20 healthy controls and 33 mild cognitive impairment (MCI) patients due to Alzheimer’s disease. Methods We assessed tau aggregates with [18F]AV1451 PET, amyloid-β depositions with [18F]AV45 PET, and volumetric microstructural changes with MRI. We validated for [18F]AV1451 standardised uptake value ratio (SUVRs) against input functions from arterial metabolites and found that SUVRs and arterial-derived distribution volume ratio (DVRs) provide equally robust measures of [18F]AV1451 binding. Results CBS patients showed increases in [18F]AV1451 SUVRs in parietal (P
اللغة: English
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9860cbab86bf3405000630847a3f6d8Test
http://hdl.handle.net/10044/1/71706Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....f9860cbab86bf3405000630847a3f6d8
قاعدة البيانات: OpenAIRE
الوصف
الوصف غير متاح.