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Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

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العنوان: Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
المؤلفون: Enrico Petretto, Mara Suleiman, Franco Filipponi, Lorella Marselli, Hassan Mziaut, Hans-Detlev Saeger, Andreas Dahl, Robin Liechti, Birgit Meyer-Puttlitz, Marius Distler, Anke Sönmez, C. Wegbrod, Katja Pfriem, Raphael Scharfmann, Sigurd Lenzen, Piero Marchetti, Afshan Siddiq, A. Friedrich, Bernard Thorens, Mark Ibberson, Daniel Margerie, Anne Jörns, Philippe Froguel, Everson Nogoceke, Mario Falchi, Florian Ehehalt, Michele Solimena, Aida Moreno-Moral, Manuela Kleeberg, Robert Grützmann, Frédéric Burdet, Anke M. Schulte, Ugo Boggi, Guy A. Rutter, Farooq Syed, Leonore Wigger, Klaus-Peter Knoch, Dorothée Sturm, Julia Parnis, Daniela Richter, Mathias Lesche, Gustavo B. Baretton, Ioannis Xenarios, Paolo Meda, Claes B. Wollheim, Jürgen Weitz, Krister Bokvist, Manon von Bulow, Marco Bugliani, Jörn Meinel, Ezio Bonifacio
المصدر: Diabetologia 61, 641–657 (2018)
Diabetologia
Diabetologia, vol. 61, no. 3, pp. 641-657
Diabetologia, Vol. 61, No 3 (2018) pp. 641-657
بيانات النشر: Springer, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Male, 0301 basic medicine, Beta cell, Biobank, Diabetes, Gene expression, Insulin secretion, Islet, Laser capture microdissection, Organ donor, Pancreatectomy, Systems biology, Internal Medicine, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, ddc:616.07, Impaired glucose tolerance, Endocrinology, 1114 Paediatrics And Reproductive Medicine, Biological Specimen Banks, Aged, 80 and over, geography.geographical_feature_category, Tissue Donors, 3. Good health, HNF1A, Aged, Computational Biology, Diabetes Mellitus, Type 2/metabolism, Female, Humans, Systems Biology/methods, Transcriptome/genetics, Diabetes and Metabolism, medicine.anatomical_structure, 1117 Public Health And Health Services, PDX1, Pancreas, endocrine system, medicine.medical_specialty, Biology, Article, Endocrinology & Metabolism, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Beta-Zelle, Biobank, Diabetes, Mikrodissektion durch Laser-Capture, Inselchen, Insulinsekretion, medicine, ddc:610, geography, Beta Cell, Gene Expression, Insulin Secretion, Laser Capture Microdissection, Organ Donor, Systems Biology, 1103 Clinical Sciences, medicine.disease, beta cell, biobank, diabetes, laser capture microdissection, islet, insulin secretion, 030104 developmental biology, Diabetes Mellitus, Type 2, Immunology, Transcriptome
الوصف: Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium (www.imidia.org) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP). Methods Affymetrix microarrays were used to assess the islet transcriptome of islets isolated either by enzymatic digestion from 103 organ donors (OD), including 84 non-diabetic and 19 type 2 diabetic individuals, or by laser capture microdissection (LCM) from surgical specimens of 103 PPP, including 32 non-diabetic, 36 with type 2 diabetes, 15 with impaired glucose tolerance (IGT) and 20 with recent-onset diabetes (
وصف الملف: application/pdf
اللغة: English
تدمد: 0012-186X
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed68b9192f383629adabf1feea42352Test
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52600Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....bed68b9192f383629adabf1feea42352
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0012186X