دورية أكاديمية
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium
| العنوان: | E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium |
|---|---|
| المؤلفون: | Horne, H.N, Oh, H, Sherman, M.E, Palakal, M, Hewitt, S.M, Schmidt, M.K, Milne, R.L, Hardisson, D, Benitez, J, Blomqvist, C, Bolla, M.K, Brenner, H, Chang-Claude, J, Cora, R, Couch, F.J, Cuk, K, Devilee, P, Easton, D.F, Eccles, D.M, Eilber, U, Hartikainen, J.M, Heikkilä, P, Holleczek, B, Hooning, M.J, Jones, M, Keeman, R, Mannermaa, A., Martens, J.W.M., Muranen, T.A, Nevanlinna, H., Olson, J.E., Orr, N., Perez, J.I.A., Pharoah, P.D.P., Ruddy, K.J., Saum, K.-U., Schoemaker, M.J., Seynaeve, C., Sironen, R., Smit, V.T.H.B.M., Swerdlow, A.J., Tengström, M., Thomas, A.S., Timmermans, A.M., Tollenaar, R.A.E.M., Troester, M.A., Van Asperen, C.J., Van Deurzen, C.H.M., Van Leeuwen, F.F., Van'T Veer, L.J., García-Closas, M., Figueroa, J.D. |
| المصدر: | Scientific Reports, 8(1) |
| بيانات النشر: | Springer |
| سنة النشر: | 2018 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | gene expression, adult, human, Receptors, Estrogen, mortality, risk factor, cadherin, case control study, estrogen receptor, Middle Aged, Biomarkers, Tumor, Aged, epidermal growth factor receptor 2, proportional hazards model, metabolism, prognosis, Progesterone, Odds Ratio, Case-Control Studies, breast tumor, female, Proportional Hazards Models, Receptor, ErbB-2, Risk Factors, Breast Neoplasms, genetics, Humans |
| الوصف: | E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/hwqw-2381Test; https://cdr.lib.unc.edu/downloads/h128nr69n?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/h128nr69nTest |
| DOI: | 10.17615/hwqw-2381 |
| الإتاحة: | https://doi.org/10.17615/hwqw-2381Test https://cdr.lib.unc.edu/downloads/h128nr69n?file=thumbnailTest https://cdr.lib.unc.edu/downloads/h128nr69nTest |
| رقم الانضمام: | edsbas.C0F306B3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/hwqw-2381 |
|---|