Adiponectin and vitamin D-binding protein are independently associated at birth in both mothers and neonates
| العنوان: | Adiponectin and vitamin D-binding protein are independently associated at birth in both mothers and neonates |
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| المؤلفون: | Spyridon N. Karras, Jody van den Ouweland, Declan P. Naughton, Duygu Gezen-Ak, Carol L. Wagner, Stergios A. Polyzos, Bruce W. Hollis, Cédric Annweiler, Erdinç Dursun, Danforth A. Newton, Kalliopi Kotsa |
| المساهمون: | Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Hippokratio General Hospital, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN) |
| المصدر: | Endocrine Endocrine, Springer, 2018, 59 (1), pp.164-174. ⟨10.1007/s12020-017-1475-2⟩ |
| بيانات النشر: | Springer, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Vitamin D-binding protein, Offspring, Endocrinology, Diabetes and Metabolism, Adipokine, Parathyroid hormone, Mothers, 030209 endocrinology & metabolism, alliedhealth, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pregnancy, Internal medicine, medicine, Vitamin D and neurology, Humans, Adiponectin, business.industry, Vitamin D-Binding Protein, Infant, Newborn, Parturition, Infant, medicine.disease, Fetal Blood, Newborn, 030104 developmental biology, Cross-Sectional Studies, Gestation, Female, business |
| الوصف: | International audience; CONTEXT: Adult body fat is associated with birth anthropometry, suggesting a role for metabolic regulators including vitamin D and the adipokines-adiponectin and irisin-which have been reported to interact but, as yet, data remain controversial.OBJECTIVE: To study (i) the relationship between vitamin D, its binding protein (VDBP) and the adipokines, adiponectin, and irisin in mothers and neonates at birth and (ii) their effects on neonate anthropometric outcomes.DESIGN: Cross-sectional study for healthy mothers with full-term and uncomplicated births.SETTING: Primary care.SUBJECTS: Seventy pairs of newly delivered neonates and their mothers.MAIN OUTCOMES FEATURES: Biochemical markers from maternal and cord: VDBP, adiponectin, irisin, calcium, albumin, parathyroid hormone, 25OHD, 1,25(OH)D. Maternal demographic and social characteristics and neonate anthropometric parameters were recorded.RESULTS: Maternal VDBP levels (364.1 ± 11.9 μg/ml) demonstrated a strong positive correlation with maternal adiponectin (4.4 ± 0.4 μg/ml) and irisin (308.8 ± 50.8 ng/ml) concentrations, which remained significant (p CONCLUSIONS: The main findings of this study are (i) the perspective of a potential independent interaction of VDBP and adiponectin in both mothers and neonates and (ii) the lack of a causative model effect of both maternal/neonatal vitamin D status and adipokine profile on neonatal anthropometry at birth, as a surrogate marker of future metabolic health of the offspring. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1355-008X 0969-711X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b27815d6a6160a1a68501dfd8703a6Test https://eprints.kingston.ac.uk/id/eprint/39832/6/Naughton-D-39832-AAM.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b6b27815d6a6160a1a68501dfd8703a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1355008X 0969711X |
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