دورية أكاديمية
Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data
العنوان: | Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data |
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المؤلفون: | Leyland, Kirsten M., Gates, Lucy S., Sanchez-Santos, Maria T., Nevitt, Michael C., Felson, David, Jones, Graeme, Jordan, Joanne M., Judge, Andrew, Prieto-Alhambra, Dani, Yoshimura, Noriko, Newton, Julia L., Callahan, Leigh F., Cooper, Cyrus, Batt, Mark E., Lin, Jianhao, Liu, Qiang, Cleveland, Rebecca J., Collins, Gary S., Arden, Nigel K. |
المصدر: | Aging Clin Exp Res |
بيانات النشر: | Springer International Publishing Springer |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Original Article, demo, envir |
الوصف: | BACKGROUND: Osteoarthritis (OA) is a chronic joint disease, with increasing global burden of disability and healthcare utilisation. Recent meta-analyses have shown a range of effects of OA on mortality, reflecting different OA definitions and study methods. We seek to overcome limitations introduced when using aggregate results by gathering individual participant-level data (IPD) from international observational studies and standardising methods to determine the association of knee OA with mortality in the general population. METHODS: Seven community-based cohorts were identified containing knee OA-related pain, radiographs, and time-to-mortality, six of which were available for analysis. A two-stage IPD meta-analysis framework was applied: (1) Cox proportional hazard models assessed time-to-mortality of participants with radiographic OA (ROA), OA-related pain (POA), and a combination of pain and ROA (PROA) against pain and ROA-free participants; (2) hazard ratios (HR) were then pooled using the Hartung–Knapp modification for random-effects meta-analysis. FINDINGS: 10,723 participants in six cohorts from four countries were included in the analyses. Multivariable models (adjusting for age, sex, race, BMI, smoking, alcohol consumption, cardiovascular disease, and diabetes) showed a pooled HR, compared to pain and ROA-free participants, of 1.03 (0.83, 1.28) for ROA, 1.35 (1.12, 1.63) for POA, and 1.37 (1.22, 1.54) for PROA. DISCUSSION: Participants with POA or PROA had a 35–37% increased association with reduced time-to-mortality, independent of confounders. ROA showed no association with mortality, suggesting that OA-related knee pain may be driving the association with time-to-mortality. FUNDING: Versus Arthritis Centre for Sport, Exercise and Osteoarthritis and Osteoarthritis Research Society International. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943431Test/ |
الإتاحة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943431Test/ |
حقوق: | undefined |
رقم الانضمام: | edsbas.18A3A61F |
قاعدة البيانات: | BASE |
الوصف غير متاح. |