مورد إلكتروني
Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring : a systematic review and meta-analysis
| العنوان: | Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring : a systematic review and meta-analysis |
|---|---|
| بيانات النشر: | Uppsala universitet, Obstetrisk forskning University of Athens University of Athens University of Athens University of Athens University of Athens Karolinska Institute University of Minnesota University of Athens University of Athens University of Athens SPRINGER 2017 |
| تفاصيل مُضافة: | Karalexi, M. A. Dessypris, N. Skalkidou, Alkistis Biniaris-Georgallis, S. -I Kalogirou, E. I. Thomopoulos, T. P. Herlenius, E. Spector, L. G. Loutradis, D. Chrousos, G. P. Petridou, E. Th. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Purpose History of fetal loss including miscarriage and stillbirth has been inconsistently associated with childhood (0-14 years) leukemia in subsequent offspring. A quantitative synthesis of the inconclusive literature by leukemia subtype was therefore conducted. Methods Eligible studies (N = 32) were identified through the screening of over 3500 publications. Random-effects meta-analyses were conducted on the association of miscarriage/stillbirth history with overall (AL; 18,868 cases/35,685 controls), acute lymphoblastic (ALL; 16,150 cases/38,655 controls), and myeloid (AML; 3042 cases/32,997 controls) leukemia. Sensitivity and subgroup analyses by age and ALL subtype, as well as meta-regression were undertaken. Results Fetal loss history was associated with increased AL risk [Odds Ratio (OR) 1.10, 95% Confidence Intervals (CI) 1.04-1.18]. The positive association was seen for ALL (OR 1.12, 95%CI 1.05-1.19) and for AML (OR 1.13, 95%CI 0.91-1.41); for the latter the OR increased in sensitivity analyses. Notably, stillbirth history was significantly linked to ALL risk (OR 1.33, 95%CI 1.02-1.74), but not AML. By contrast, the association of ALL and AML with previous miscarriage reached marginal significance. The association of miscarriage history was strongest in infant ALL (OR 2.34, 95%CI 1.19-4.60). Conclusions In this meta-analysis involving > 50,000 children, we found noteworthy associations by indices of fetal loss, age at diagnosis, and leukemia type; namely, of stillbirth with ALL and miscarriage history with infant ALL. Elucidation of plausible underlying mechanisms may provide insight into leukemia pathogenesis and indicate monitoring interventions prior to and during pregnancy. |
| مصطلحات الفهرس: | Miscarriage, Stillbirth, Childhood acute lymphoblastic leukemia, Childhood acute myeloid leukemia, Meta-analysis, Meta-regression, Cancer and Oncology, Cancer och onkologi, Article, review/survey, info:eu-repo/semantics/article, text |
| DOI: | 10.1007.s10552-017-0890-2 |
| URL: | Cancer Causes and Control, 0957-5243, 2017, 28:6, s. 599-624 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:uu-328824 0000-0002-4935-7532 doi:10.1007/s10552-017-0890-2 PMID 28401353 ISI:000399833500010 1233431057 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1233431057 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1007.s10552-017-0890-2 |
|---|