المؤلفون: Koch, Kenneth L., Hasler, William L., Van Natta, Mark, Calles‐escandon, Jorge, Grover, Madhusudan, Pasricha, Pankaj J., Snape, William J., Parkman, Henry P., Abell, Thomas L., McCallum, Richard W., Nguyen, Linda A., Sarosiek, Irene, Farrugia, Gianrico, Tonascia, James, Lee, Linda, Miriel, Laura, Hamilton, Frank

مصطلحات موضوعية: diabetic gastroparesis, patient assessment of upper GI symptoms, gastroparesis cardinal symptom index, gastric myoelectrical activity, gastric dysrhythmias, caloric and nonâ caloric test meals, Internal Medicine and Specialties, Health Sciences

الوصف: BackgroundSymptoms induced by caloric or nonâ caloric satiety test meals and gastric myoelectrical activity (GMA) have not been studied in patients with diabetic gastroparesis (DGP) before and after intense glucose management.AimsWe determined the effects of continuous subcutaneous insulin infusion (CSII) with continuous glucose monitoring (CGM) on GI symptoms, volume consumed, and GMA induced by the caloric meal satiety test (CMST) and water load satiety test (WLST) in DGP.MethodsFortyâ five patients with DGP underwent CMST and WLST at baseline and 24 weeks after CSII with CGM. Subjects ingested the test meals until they were completely full. Visual analog scales were used to quantify preâ and postmeal symptoms, and GMA was recorded with cutaneous electrodes and analyzed visually and by computer.Key ResultsAt baseline and 24â week visits, nausea, bloating, abdominal discomfort, and fullness were immediately increased after CMST and WLST (Ps < 0.01). The meal volumes ingested were significantly less than normal controls at both visits in almost oneâ third of the subjects. After the CMST, the percentage 3 cycle per minute GMA increased and bradygastria decreased compared with WLST (Ps < 0.05). After treatment for 24 weeks meal volumes ingested, postmeal symptoms and GMA were no different than baseline.Conclusions and inferences(a) Satiety test meals elicited symptoms of nausea, bloating, and abdominal discomfort; (b) CMST stimulated more symptoms and changes in GMA than WLST; and (c) CSII with CGM for 24 weeks did not improve symptoms, volumes ingested, or GMA elicited by the two satiety test meals in these patients with diabetic GP. Satiety tests in diabetic gastropresis are useful to study acute postprandial symptoms and GMA, but these measures were not improved by intensive insulin therapy.Water load and caloric load satiety tests immediately increase symptoms associated with gastroparesis. Normal 3 cpm gastric myoelctrical activity increased more after caloric load than water load tests. ...

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العلاقة: Koch, Kenneth L.; Hasler, William L.; Van Natta, Mark; Calles‐escandon, Jorge; Grover, Madhusudan; Pasricha, Pankaj J.; Snape, William J.; Parkman, Henry P.; Abell, Thomas L.; McCallum, Richard W.; Nguyen, Linda A.; Sarosiek, Irene; Farrugia, Gianrico; Tonascia, James; Lee, Linda; Miriel, Laura; Hamilton, Frank (2020). "Satiety testing in diabetic gastroparesis: Effects of insulin pump therapy with continuous glucose monitoring on upper gastrointestinal symptoms and gastric myoelectrical activity." Neurogastroenterology & Motility 32(1): n/a-n/a.; https://hdl.handle.net/2027.42/152474Test; Neurogastroenterology & Motility; Pasricha PJ, Colvin R, Yates K, et al. Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol. 2011; 9: 567 â 576.; Karamanolis G, Caenepeel P, Arts J, Tack J. Determinants of symptom pattern in idiopathic severely delayed gastric emptying: gastric emptying rate or proximal stomach dysfunction? Gut. 2007; 56: 29 â 36.; Koch KL, Hasler WL, Yates KP, et al. Baseline features and differences in 48 weeks clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes. Neurogastroenterol Mot. 2016; 28: 1001 â 1015.; Cipriani G, Gibbons SJ, Miller KE, et al. Change in populations of macrophages promotes development of delayed gastric emptying in mice. Gastroenterol. 2018; 154: 2122 â 2136.; Lydon A, Murray C, Cooke T, Duggan PF, Oâ Halloran D, Shorten GD. Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus. Eur J Anaesthesiol. 2000; 17: 99 â 104.; Reddy S, Ramsubeik K, Vega KJ, Federico J, Palacio C. Do HbA1c levels correlate with delayed gastric emptying in diabetic patients? J Neurogastroenterol Motil. 2010; 16: 414 â 417.; Wellington J, Scott B, Kundu S, Stuart P, Koch KL. Effect of endoscopic pyloric therapies for patients with nausea and vomiting and functional obstructive gastroparesis. Auton Neurosci. 2017; 202: 56 â 61.; Brzana RJ, Koch KL, Bingaman S. Gastric myoelectrical activity in patients with gastric outlet obstruction and idiopathic gastroparesis. Am J Gastroenterol. 1998; 93: 1803 â 1809.; Faussoneâ Pellegrini MS, Grover M, Pasricha PJ, et al. Ultrastructural differences between diabetic and idiopathic gastroparesis. J Cell Mol Med. 2012; 16: 1573 â 1581.; Jebbink RJ, Samsom M, Bruijs PP, et al. Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type 1 diabetes mellitus. Gastroenterol. 1994; 107: 1390 â 1397.; Coleski R, Hasler WL. Coupling and propagation of normal and dysrhythmic gastric slow waves during acute hyperglycemia in healthy humans. Neurogastroenterol Motil. 2009; 21: 492 â 499.; Ladabaum U, Koshy SS, Woods ML, Hooper FG, OwYang C, Hasler WL. Differential symptomatic and electrogastrography effects of distal and proximal gastric stimulation. Am J Physiol. 1999; 275: G418 â G424.; Oâ Grady G, Angeli T, Du P, et al. Abnormal initiation and conduction of slowâ wave activity in gastroparesis, defined by highâ resolution electrical mapping. Gastroenterol. 2012; 143: 589 â 598.; Grover M, Bernard CE, Pasricha PJ, et al. Clinicalâ histological associations in gastroparesis: results from the gastroparesis clinical research consortium. Neurogastroenterol Motil. 2012; 24: 5319.; Jones MP, Hoffman S, Shah D, Patek K, Ebert CC. The water load test: observations from healthy controls and patients with functional dyspepsia. Am J Physiol Gastrointest Liver Physiol. 2003; 284 ( 6 ): G896 â 904.; StataCorp. Stata Statistical Software: Release 15. College Station, TX: StataCorp LLC; 2017.; SAS Institute Inc. SAS version 9.4, SAS Institute Inc., Cary, NC.; Koch KL. Electrogastrography for Evaluation of Patients with Suspected Gastroparesis. In: Parkman H, McCallum R,eds. Gastroparesis: Pathophysiology, Presentation, Diagnosis and Treatment. N ew York, NY: Springer; 2011: 153 â 161.; Tougas G, Eaker EY, Abell TL, et al. Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol. 2000; 95: 1456 â 1462.; Callesâ Escandon J, Koch KL, Hasler WL, et al. Glucose sensorâ augmented subcutaneous insulin infusion in patients with diabetic gastroparesis: an openâ label prospective study. PLoS ONE. 2018; 13: e0194759.; Parkman HP, Hallinan EK, Hasler WL, et al. satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing. Neurogastroenterol Motil. 2017; 29 ( 4 ): e12981.; Koch KL, Hong SP, Xu L. Reproducibility of gastric myoelectrical activity and the water load test in patients with dysmotilityâ like dyspepsia symptoms and in control subjects. J Clin Gastroenterol. 2000; 31: 125 â 129.; Kumar A, Attaluri A, Hashmi S, Schulze KS, Rao SS. Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis. Gastroenterol Motil. 2008; 20: 635 â 642.; Kindt S, Coulie B, Wajs E, Janssens J, Tack J. Reproducibility and symptomatic predictors of a slow nutrient drink test in health and in functional dyspepsia. Neurogastroenterol Motil. 2008; 20: 320 â 329.; Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterol. 2001; 121: 526 â 535.

الإتاحة: https://doi.org/10.1111/nmo.13720Test
https://hdl.handle.net/2027.42/152474Test

المؤلفون: Koch, Kenneth L., Hasler, William L., Van Natta, Mark, Calles‐escandon, Jorge, Grover, Madhusudan, Pasricha, Pankaj J., Snape, William J., Parkman, Henry P., Abell, Thomas L., McCallum, Richard W., Nguyen, Linda A., Sarosiek, Irene, Farrugia, Gianrico, Tonascia, James, Lee, Linda, Miriel, Laura, Hamilton, Frank

مصطلحات موضوعية: diabetic gastroparesis, patient assessment of upper GI symptoms, gastroparesis cardinal symptom index, gastric myoelectrical activity, gastric dysrhythmias, caloric and nonâ caloric test meals, Internal Medicine and Specialties, Health Sciences, psy, socio

الوصف: BackgroundSymptoms induced by caloric or nonâ caloric satiety test meals and gastric myoelectrical activity (GMA) have not been studied in patients with diabetic gastroparesis (DGP) before and after intense glucose management.AimsWe determined the effects of continuous subcutaneous insulin infusion (CSII) with continuous glucose monitoring (CGM) on GI symptoms, volume consumed, and GMA induced by the caloric meal satiety test (CMST) and water load satiety test (WLST) in DGP.MethodsFortyâ five patients with DGP underwent CMST and WLST at baseline and 24 weeks after CSII with CGM. Subjects ingested the test meals until they were completely full. Visual analog scales were used to quantify preâ and postmeal symptoms, and GMA was recorded with cutaneous electrodes and analyzed visually and by computer.Key ResultsAt baseline and 24â week visits, nausea, bloating, abdominal discomfort, and fullness were immediately increased after CMST and WLST (PsÂ

العلاقة: https://hdl.handle.net/2027.42/152474Test

الإتاحة: https://hdl.handle.net/2027.42/152474Test