Highlights 1. MET is a direct target of miR-27b. 2. Low expression of miR-27b is correlated with the growth activity of DLBCL cells. 3. miR-27b inhibits the proliferation and invasiveness of DLBCL cells, and promotes the apoptosis of the cells by targeting MET and inhibiting the activity of the MET/PI3K/AKT pathway.