Level of fluorodeoxyglucose uptake predicts risk for recurrence in melanoma patients presenting with lymph node metastases
| العنوان: | Level of fluorodeoxyglucose uptake predicts risk for recurrence in melanoma patients presenting with lymph node metastases |
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| المؤلفون: | Harald J. Hoekstra, E. Bastiaannet, Theo Wobbes, Wim J.G. Oyen, Piet L. Jager, Otto S. Hoekstra |
| المساهمون: | Radiology and nuclear medicine |
| المصدر: | Bastiaannet, E, Hoekstra, O S, Oyen, W J G, Jager, P L, Wobbes, T & Hoekstra, H J 2006, ' Level of fluorodeoxyglucose uptake predicts risk for recurrence in melanoma patients presenting with lymph node metastases ', Annals of Surgical Oncology, vol. 13, no. 7, pp. 919-926 . https://doi.org/10.1245/ASO.2006.02.007Test Annals of Surgical Oncology, 13(7), 919-926. Springer New York Annals of Surgical Oncology, 13(7), 919-926. SPRINGER Annals of Surgical Oncology, 13, 7, pp. 919-26 Annals of Surgical Oncology, 13, 919-26 |
| بيانات النشر: | SPRINGER, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Oncology, Pathology, Skin Neoplasms, Multivariate analysis, STANDARDIZED UPTAKE VALUE, Aetiology, screening and detection [ONCOL 5], PANCREATIC-CARCINOMA, Risk Factors, Surgical oncology, fluorodeoxyglucose-positron emission tomography, FDG-PET, Lymph node, Aged, 80 and over, medicine.diagnostic_test, Melanoma, FLOW-CYTOMETRY, Middle Aged, Prognosis, Pathogenesis and modulation of inflammation [N4i 1], Survival Rate, PROGNOSTIC VALUE, medicine.anatomical_structure, Positron emission tomography, Lymphatic Metastasis, Disease Progression, Female, SQUAMOUS-CELL CARCINOMA, medicine.drug, lymph node metastases, Adult, medicine.medical_specialty, disease-free survival, Standardized uptake value, survival, POSITRON-EMISSION-TOMOGRAPHY, LUNG-CANCER, Translational research [ONCOL 3], Fluorodeoxyglucose F18, Internal medicine, medicine, melanoma, Humans, Lung cancer, Aged, Retrospective Studies, Fluorodeoxyglucose, business.industry, CUTANEOUS MALIGNANT-MELANOMA, medicine.disease, ROI DEFINITION, Positron-Emission Tomography, Surgery, Functional Imaging [UMCN 1.1], standard uptake value, Neoplasm Recurrence, Local, Radiopharmaceuticals, business |
| الوصف: | Contains fulltext : 50714.pdf (Publisher’s version ) (Closed access) BACKGROUND: The incidence of malignant melanoma has increased. Identification of additional prognostic factors may allow the development of individualized strategies. This multivariate analysis was undertaken to evaluate the potential role of the standard uptake value (SUV) in predicting disease-free and overall survival in melanoma patients with lymph node metastases. METHODS: All melanoma patients with palpable lymph node metastases who where referred for a fluorodeoxyglucose positron emission tomography scan were eligible. The SUV in the lymph node metastasis was calculated. Data were analyzed (Kaplan-Meier), and differences in cumulative survival and the disease-free rate were assessed (log-rank test). Univariate and multivariate analyses (Cox proportional hazard model) were performed to determine independent prognostic factors. RESULTS: There was no statistical difference in survival for the 38 patients with a high or low SUVmean (P = .11). However, a significant difference was found in disease-free survival (P = .03). Ulceration of the primary melanoma (P = .023) was an independent predictor of survival. For the disease-free survival, multivariate Cox regression showed adjuvant radiation (P = .001), localization of the primary melanoma (P = .017), and a high SUVmean (P = .009) as independent prognostic factors. CONCLUSIONS: Disease-free survival of melanoma patients was prolonged in those with a low SUVmean value (P = .03) in their lymph node metastasis, as compared with those with a high SUVmean. However, this difference was not found for overall survival. In multivariate analysis, high SUVmean was an independent prognostic factor (P = .009) for disease-free survival. Prospective research should determine whether patients with a high FDG uptake in melanoma lymph node metastases could benefit from adjuvant radiation treatment or chemotherapy. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1534-4681 1068-9265 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec151f01fdc7fc21adc632456f0a707Test https://doi.org/10.1245/ASO.2006.02.007Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....0ec151f01fdc7fc21adc632456f0a707 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15344681 10689265 |
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