Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice
| العنوان: | Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice |
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| المؤلفون: | Fiona Peris-Sampedro, Cristina Suñol, Leticia Campa, Ingrid Reverte, José L. Domingo, Maria Teresa Colomina, Pia Basaure, Margarita Moreno |
| المساهمون: | Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Generalitat de Catalunya, European Commission |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Springer, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein E, Apolipoprotein E2, Dopamine, Apolipoprotein E4, Apolipoprotein E3, Cholinergic Agents, Executive Function, Mice, 0302 clinical medicine, ApolipoproteinE, ApoE, Visuospatialattention, Impulsivity, 5-CSRTT, Acetylcholine, Dopamine, Glutamate, Striatum, Frontal cortex, Attention, Neurotransmitter Agents, Executive functions, Inhibition, Psychological, Female, lipids (amino acids, peptides, and proteins), medicine.symptom, Glutamate, Psychology, medicine.drug, ApoE, medicine.medical_specialty, Impulsivity, Visuospatial attention, GABA Agents, Perseveration, Mice, Transgenic, Frontal cortex, Striatum, 03 medical and health sciences, Neurochemical, Internal medicine, Reaction Time, medicine, Animals, Humans, Pharmacology, Acetylcholine, Mice, Inbred C57BL, 030104 developmental biology, Monoamine neurotransmitter, Endocrinology, Space Perception, Impulsive Behavior, Cholinergic, 5-CSRTT, Neuroscience, Psychomotor Performance, 030217 neurology & neurosurgery |
| الوصف: | Rationale: The apolipoprotein E (apoE) genotype influences cognitive performance in humans depending on age and sex. While the detrimental role of the apoE4 isoform on spatial learning and memory has been well-established in humans and rodents, less is known on its impact on the executive functions. Objectives: We aimed to evaluate the effect of apoE isoforms (apoE2, apoE3, apoE4) on visuospatial attention and inhibitory control performance in female transgenic mice, and to determine the neurochemical and neuropharmacological basis of this potential relationship. Methods: Female mice carrying apoE2, apoE3, and apoE4 were trained in the five-choice serial reaction time task (5-CSRTT). Upon a stable performance, we manipulated the inter-trial interval and the stimulus duration to elicit impulsive responding and engage attention respectively. We further performed a pharmacological challenge by administering cholinergic and GABAergic agents. Finally, we analyzed the levels of brain amino acids and monoamines by using reversed phase high-performance liquid chromatography (HPLC). Results: ApoE4 mice showed a deficient inhibitory control as revealed by increased perseveration and premature responding. When attention was challenged, apoE4 mice also showed a higher drop in accuracy. The adverse effect of scopolamine on the task was attenuated in apoE4 mice compared to apoE2 and apoE3. Furthermore, apoE4 mice showed less dopamine in the frontal cortex than apoE2 mice. Conclusions: We confirmed that the apoE genotype influences attention and inhibitory control in female transgenic mice. The influence of apoE isoforms in the brain neuromodulatory system may explain the cognitive and behavioral differences attributable to the genotype. This research was supported by PSI2010-21743-C02-01, the Ministry of the Economy and Competitiveness (MINECO, Spain), and PI 13/01252 from the Instituto de Salud Carlos III (ISCIII, Spain), the European Regional Development Fund (ERDF), the Commission for Universities and Research of the Department of Innovation, Universities and Enterprise of the Generalitat de Catalunya (2009 FI-B 00256/2010 and BE-1 0072), and the European Social Fund |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83a45316acacecdc74f901475bcc5c3Test http://hdl.handle.net/10261/136566Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d83a45316acacecdc74f901475bcc5c3 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |