التفاصيل البيبلوغرافية
| العنوان: |
Endosialin-expressing bone sarcoma stem-like cells are highly tumor-initiating and invasive. |
| المؤلفون: |
DONG-XIU SUN, GUANG-JUN LIAO, KE-GUI LIU, HAN JIAN |
| المصدر: |
Molecular Medicine Reports; 2015, Vol. 12 Issue 4, p5665-5670, 6p |
| مصطلحات موضوعية: |
GENE expression, OSTEOSARCOMA, CANCER stem cells, CANCER relapse, CANCER cell proliferation |
| مستخلص: |
It has been reported that the presence of a small group of cancer stem-like 'side population (SP)' cells is responsible for therapy failure and tumor recurrence. The present study demonstrated that primary human osteosarcoma samples contained a SP of about 3.9% which overexpressed ABC transporters, including ABCA1, ABCB1, ABCB2 and ABCG2, which are associated with drug resistance and may have contributed to multi-drug resistance of SP cells. Furthermore, these SP cells displayed increased expression of endosialin (CD248) and other stem cell surface proteins, including CD133, octamer-binding transcription factor 3/4A, Nanog and Nestin, which are ultimately responsible for high self-renewal and deregulated cell proliferation. In addition, it was shown that endosialin-overexpressing SP cells were able to regenerate the tumor population and had a high invasive potential. Therefore, the present study suggested that osteosarcoma SP cells were cancer stem cells, as they displayed stem-like properties; furthermore, endosialin may be a potential target to prevent osteosarcoma recurrence following chemotherapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
