MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3
| العنوان: | MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3 |
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| المؤلفون: | Chuan Wang, Chengye Hong, Bo Ma, Xi Zhang, Debo Chen, Zhipeng Hong, Liangqiang Li, Qinglan Wang |
| المصدر: | Oncology Reports. |
| بيانات النشر: | Spandidos Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Angiogenesis, Cell, Triple Negative Breast Neoplasms, Biology, 03 medical and health sciences, 0302 clinical medicine, Vasculogenesis, Cell Movement, Cell Line, Tumor, medicine, Humans, Genes, Tumor Suppressor, Neoplasm Invasiveness, Vasculogenic mimicry, Triple-negative breast cancer, Neovascularization, Pathologic, Oncogene, Cell growth, General Medicine, Cell cycle, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Cancer research, Female, RGS Proteins |
| الوصف: | Triple‑negative breast cancer (TNBC) is characterized by fast progression with high potential for metastasis, and poor prognosis. The dysregulation of microRNAs (miRNAs) occurring in the initiation or progression of cancers often leads to aberrant gene expression. The aim of the present study was to explore the function of miR‑126 in TNBC cells. Expression levels of miR‑126‑3p were determined by quantitative real‑time PCR. Then, the effects of miR‑126‑3p on migration, proliferation, invasion, and angiogenesis were assessed through in vitro experiments including Cell Counting Kit‑8, colony formation, Transwell invasion and vasculogenic mimicry formation assays. One of the target genes for miR‑126‑3p predicted by TargetScan was confirmed by luciferase activity assay. Results indicated that miR‑126‑3p expression was reduced in TNBC cell lines. Functional assays revealed that miR‑126‑3p overexpression inhibited cell proliferation, migration, invasion, colony formation capacity and vasculogenesis by 1.2‑, 1.8‑, 2.3‑, 2.0‑ and 3.3‑fold, respectively, compared to the miRNA‑negative control group of MDA‑MB‑231 cells (P |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f617af060a7d928b829b6255696894a4Test https://doi.org/10.3892/or.2019.7251Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f617af060a7d928b829b6255696894a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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