Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population
| العنوان: | Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population |
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| المؤلفون: | Rosmawati Mohamed, Behnaz Riazalhosseini, Zahurin Mohamed, Noor Shafila Shafie, Yamunah Devi Apalasamy |
| المصدر: | Biomedical Reports. |
| بيانات النشر: | Spandidos Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Hepatitis B virus, business.industry, General Neuroscience, medicine.medical_treatment, Haplotype, Single-nucleotide polymorphism, Articles, General Medicine, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, Immune system, Cytokine, Infectious disease (medical specialty), Immunology, Genotype, Medicine, General Pharmacology, Toxicology and Pharmaceutics, Allele, business |
| الوصف: | Interleukin-6 (IL-6) is a cytokine with a critical role in regulating the immune response to infectious disease. Studies have indicated that polymorphisms in the IL-6 gene may be linked to hepatitis B virus (HBV) infection. The purpose of the present study was to examine the association among IL-6 SNPs and haplotypes with HBV infection risk in a Malaysian population. A total of 1,246 Malaysian subjects with and without chronic hepatitis B were recruited for this study. Three IL-6 polymorphisms (rs2069837, rs1800796 and rs2066992) were genotyped using a Sequenom MassARRAY® platform. The results suggested that GC and CC genotypes of rs1800796 as well as GT and TT genotypes of rs2066992 were associated with protection against HBV infection (P |
| تدمد: | 2049-9442 2049-9434 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d36174c515b67a3dce2fc86939347a1Test https://doi.org/10.3892/br.2018.1126Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d36174c515b67a3dce2fc86939347a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20499442 20499434 |
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