Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis
| العنوان: | Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis |
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| المؤلفون: | Yan Qi, Lijuan Pang, Hong Zou, Xinxin Ju, Yang Zhou, Shugang Li, Ruixue Liu, Jinfang Jiang, Feng Li, Yao-Yuan Shen, Dongdong Chen, Weihua Liang, Jiaojiao Lan |
| المصدر: | Oncology Reports. 37:3351-3360 |
| بيانات النشر: | Spandidos Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Adolescent, Oncogene Proteins, Fusion, medicine.disease_cause, Aldehyde Dehydrogenase 1 Family, Nestin, Sarcoma, Synovial, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cancer stem cell, Biomarkers, Tumor, medicine, Humans, AC133 Antigen, Child, biology, Integrin beta1, CD44, Retinal Dehydrogenase, Cancer, General Medicine, Middle Aged, Prognosis, medicine.disease, Synovial sarcoma, Gene Expression Regulation, Neoplastic, Isoenzymes, Hyaluronan Receptors, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Cancer research, biology.protein, Female, Sarcoma, Stem cell, Carcinogenesis |
| الوصف: | Synovial sarcoma (SS) is an aggressive soft tissue tumor, with uncertain histological and cellular origin. SYT-SSX is considered to be responsible for sarcoma initiation and progression. The histogenesis and pathogenesis of this tumor are poorly understood, and prognosis of patients of SS is unsatisfactory. Recent studies have shown an association of cancer stem cells with the initiation and development of tumors. We explored immunohistochemical expression level of stem cell associated markers to determine the possible histogenesis and pathogenesis of SS. Fusion gene SYT-SSX was tested to assess diagnostic value and the molecular pathological features. We obtained the clinicopathological data of 20 SS patients, immunohistochemical staining were used to evaluate stem cell-associated markers included CD133, CD29, CD44, nestin, and ALDH1. Fusion gene SYT-SSX was tested by reverse transcriptase-polymerase chain reaction (RT-PCR). Twenty SS cases were observed and the positive immuno-expression results showed CD133 (17/20), CD29 (11/20), CD44 (11/20), nestin (6/20), and ALDH1 (5/20). Fusion gene SYT-SSX was successfully detected by RT-PCR from 18 available samples. The expression of stem cell-associated markers (CD133, CD29, CD44, Nestin, and ALDH1) and clinical data (age, gender, sites, tumor size, histological type, tumor stage, and distant metastases) did not show statistically significant relationship (P>0.05), whereas, statistically significance between ALDH1 and metastases was observed (P |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae711f853e5475fc3ed2604087b8420bTest https://doi.org/10.3892/or.2017.5617Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae711f853e5475fc3ed2604087b8420b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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