Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression
| العنوان: | Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression |
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| المؤلفون: | Jean-Olivier Contreres, Patricia Hainaud, Evelyne Dupuy, Clarisse Eveno, Marc Pocard, Judith Nemeth |
| المصدر: | Oncology Reports. 29:73-78 |
| بيانات النشر: | Spandidos Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Colorectal cancer, Mice, Nude, Metastasis, Mice, Internal medicine, Tumor Cells, Cultured, medicine, Animals, Humans, Nerve Growth Factors, Lymph node, Oncogene, business.industry, Liver Neoplasms, Cancer, General Medicine, Cell cycle, medicine.disease, Primary tumor, Molecular medicine, medicine.anatomical_structure, Lymphatic Metastasis, Colonic Neoplasms, Disease Progression, Cancer research, Female, Netrins, Neoplasm Recurrence, Local, business |
| الوصف: | Tumor angiogenesis is closely associated with clinical staging and has been proposed to correlate with clinical response in terms of subsequent metastases following primary resection. Netrin-4 (NT-4) regulates angiogenic responses. Therefore, we sought to examine the effects of NT-4 on the primary tumor growth of colon cancer cells, liver and lung metastases of colon cancer cells, and responses following primary tumor resection. We used 3 different mouse models of orthotopic primary tumor and liver and lung metastases, comparing 2 human colon cancer cells lines: wild-type (low expression of NT-4) and NT-4 (overexpression of NT-4) LS174 cells. NT-4 overexpression inhibited the primary tumor growth of colorectal LS174 xenografts in nude mice (144.3±12.9 vs. 62.4±4.5 mm3; p |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d554102e8bae9bbe290c003647051cf1Test https://doi.org/10.3892/or.2012.2104Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d554102e8bae9bbe290c003647051cf1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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