Microcirculation and metastasis in a new mouse mammary tumor model system
| العنوان: | Microcirculation and metastasis in a new mouse mammary tumor model system |
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| المؤلفون: | Lawrence J T Young, Assane Ndoye, Peter A. Barry, Peter C Y Chen, Robert D. Cardiff, William J. Muller, Anthony T.W. Cheung, Chien Y. Chao |
| المصدر: | International Journal of Oncology. |
| بيانات النشر: | Spandidos Publications, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Mammary tumor, Oncogene, Angiogenesis, Transgene, Histology, Biology, medicine.disease, Metastasis, Microcirculation, Oncology, medicine, Intravital microscopy |
| الوصف: | Two new metastatic mouse mammary tumor transplant lines have been established in nude mice. The Met-1 line, with the polyoma virus middle T (PyV-MT) transgene, metastasized with 100% efficiency. The Db-7 line, expressing a PyV-MT transgene mutated at positions 315 and 322, metastasized with 8.8% efficiency. Histology and computer-assisted intravital microscopy demonstrated that internal microcirculation in Met-1 was more complex than Db-7; Met-1 exhibited higher microvessel density and tortuosity (P < 0.0001). These indices of microvascular complexity correlated with the higher Met-1 metastatic rate (P < 0.0001). These two transplantable lines will be useful for investigating the complex relationship between angiogenesis and metastasis. |
| تدمد: | 1791-2423 1019-6439 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::98acf124f2ff2a0cc3aa589eb7d72e7dTest https://doi.org/10.3892/ijo.11.1.69Test |
| رقم الانضمام: | edsair.doi...........98acf124f2ff2a0cc3aa589eb7d72e7d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912423 10196439 |
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