Association between genetic polymorphisms in thecyclooxygenase-1 gene promoter and peptic ulcers in Japan
| العنوان: | Association between genetic polymorphisms in thecyclooxygenase-1 gene promoter and peptic ulcers in Japan |
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| المؤلفون: | Hiroshi Fujita, Masahiko Nakamura, Masaaki Okubo, Daisuke Yoshioka, Ichiro Hirata, Tomoyuki Shibata, Masakatsu Nakamura, Yuko Arima, Tomomitsu Tahara, Mitsuo Nagasaka, Tomiyasu Arisawa, Hiroshi Nakano, Yoshio Kamiya |
| المصدر: | International Journal of Molecular Medicine. |
| بيانات النشر: | Spandidos Publications, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Peptic Ulcer, medicine.medical_specialty, Peptic, Chronic gastritis, Polymorphism, Single Nucleotide, Gastroenterology, Helicobacter Infections, Japan, Risk Factors, Internal medicine, Biopsy, Genetics, medicine, Gastric mucosa, Humans, Stomach Ulcer, Allele, Promoter Regions, Genetic, Aged, DNA Primers, Polymorphism, Genetic, Base Sequence, Helicobacter pylori, biology, medicine.diagnostic_test, business.industry, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, digestive system diseases, medicine.anatomical_structure, Gastric Mucosa, Duodenal Ulcer, Immunology, Cyclooxygenase 1, Female, Gene polymorphism, Atrophy, Gastritis, medicine.symptom, business |
| الوصف: | Cyclooxygenase-1 (COX-1) has been regarded as a constitutively expressed enzyme that generates prostaglandins for gastrointestinal integrity. We attempted to clarify the association between potentially functional polymorphisms (T-1676C and A-842G/C50T) in the COX-1 gene promoter and gastroduodenal disorders in a Japanese population. The study was performed with 480 stocked DNAs from subjects (gastric ulcers in 93 subjects and duodenal ulcers in 44) with no evidence of gastric malignancy. We employed the PCR-SSCP method to detect gene polymorphisms. The severity of histological chronic gastritis in antral biopsy specimens was classified according to the updated Sydney system. The T-1676C polymorphism was not associated with either gastric mucosal atrophy or infiltration of inflammatory cells into gastric mucosa. In non-NSAID (non-steroidal anti-inflammatory drug) users, male gender and Helicobacter pylori (HP) infection were significantly associated with both gastric and duodenal ulcers, whereas the -1676T allele carrier was significantly associated with only gastric ulcers (OR, 2.86; 95% CI, 1.29-6.34). In NSAID users, the number of -1676T alleles was significantly associated with developing gastroduodenal ulcers (OR, 5.80; 95% CI, 1.59-21.1), whereas male gender and HP infection were not. The -842T/ C50T polymorphism was not detected in any of the 480 Japanese subjects. In conclusion, a carrier of the -1676T allele in the COX-1 gene promoter, as well as HP infection and male gender, seem to be significant risk factors for developing gastric ulcers, and the number of -1676T alleles was also a significant risk factor for the NSAID-induced ulcer, whereas the frequency of the A-842G polymorphism was thought to be very rare in the Japanese population. |
| تدمد: | 1791-244X 1107-3756 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb26dd979ad824ba512892b830376bcTest https://doi.org/10.3892/ijmm.20.3.373Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fbb26dd979ad824ba512892b830376bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1791244X 11073756 |
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