التفاصيل البيبلوغرافية
| العنوان: |
Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth † |
| المؤلفون: |
Priyadarshini Pantham, Don L. Armstrong, Jonathan Bodnariuc, Owen Haupt, Amy Wagoner Johnson, Lori Underhill, Renato V. Iozzo, Beatrice E. Lechner, Derek E. Wildman |
| المساهمون: |
Priyadarshini Pantham, Don L. Armstrong, Jonathan Bodnariuc, Owen Haupt, Amy Wagoner Johnson, Lori Underhill, Renato V. Iozzo, Beatrice E. Lechner, Derek E. Wildman |
| المصدر: |
https://doi.org/10.1093/biolre/ioaa205Test. |
| بيانات النشر: |
Society for the Study of Reproduction |
| سنة النشر: |
2020 |
| المجموعة: |
BioOne Online Journals |
| جغرافية الموضوع: |
world |
| الوصف: |
Approximately, 25% of all preterm births are due to preterm premature rupture of membranes. Mice deficient in proteoglycans biglycan (Bgn) and decorin (Dcn) display abnormal fetal membranes and increased incidence of preterm birth. We conducted RNA-Seq to profile fetal membranes and identify molecular pathways that may lead to preterm birth in double knockout (DKO) mice (Bgn–/–; Dcn–/–) compared to wild-type (WT) at two different gestational stages, E12 and E18 (n = 3 in each group). 3264 transcripts were differentially regulated in E18 DKO vs. WT fetal membranes, and 96 transcripts differentially regulated in E12 DKO vs. WT fetal membranes (FDR 10) for transcription factor binding sites for Nr2f1 at E18. We propose that in DKO mice, cell cycle arrest results in lack of cell proliferation in fetal membranes, inability to contain the growing fetus, and preterm birth.Summary sentenceWe have conducted transcriptomic profiling of fetal membranes from mice deficient in biglycan and decorin and identified molecular pathways of interest. |
| نوع الوثيقة: |
text |
| وصف الملف: |
text/HTML |
| اللغة: |
English |
| DOI: |
10.1093/biolre/ioaa205 |
| الإتاحة: |
https://doi.org/10.1093/biolre/ioaa205Test |
| حقوق: |
All rights reserved. |
| رقم الانضمام: |
edsbas.3E682848 |
| قاعدة البيانات: |
BASE |
