Network Structure Shapes Spontaneous Functional Connectivity Dynamics
| العنوان: | Network Structure Shapes Spontaneous Functional Connectivity Dynamics |
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| المؤلفون: | Kelly Shen, Gleb Bezgin, Stefan Everling, Anthony R. McIntosh, R. M. Hutchison |
| المصدر: | Brain and Mind Institute Researchers' Publications |
| بيانات النشر: | Society for Neuroscience, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | large-scale dynamics, Male, Computer science, Models, Neurological, Network structure, Brain mapping, Macaque, Stability (probability), biology.animal, Neural Pathways, Image Processing, Computer-Assisted, Animals, structural connectivity, rich club organization, Topology (chemistry), Dynamic functional connectivity, Brain Mapping, Communication, biology, business.industry, General Neuroscience, Functional connectivity, functional connectivity, Information processing, Brain, Articles, Magnetic Resonance Imaging, Oxygen, Macaca fascicularis, Nonlinear Dynamics, functional MRI, Female, business, Biological system |
| الوصف: | The structural organization of the brain constrains the range of interactions between different regions and shapes ongoing information processing. Therefore, it is expected that large-scale dynamic functional connectivity (FC) patterns, a surrogate measure of coordination between brain regions, will be closely tied to the fiber pathways that form the underlying structural network. Here, we empirically examined the influence of network structure on FC dynamics by comparing resting-state FC (rsFC) obtained using BOLD-fMRI in macaques (Macaca fascicularis) to structural connectivity derived from macaque axonal tract tracing studies. Consistent with predictions from simulation studies, the correspondence between rsFC and structural connectivity increased as the sample duration increased. Regions with reciprocal structural connections showed the most stable rsFC across time. The data suggest that the transient nature of FC is in part dependent on direct underlying structural connections, but also that dynamic coordination can occur via polysynaptic pathways. Temporal stability was found to be dependent on structural topology, with functional connections within the rich-club core exhibiting the greatest stability over time. We discuss these findings in light of highly variable functional hubs. The results further elucidate how large-scale dynamic functional coordination exists within a fixed structural architecture. |
| تدمد: | 1529-2401 0270-6474 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b359d977c570b26503ac78033c2217Test https://doi.org/10.1523/jneurosci.4903-14.2015Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....69b359d977c570b26503ac78033c2217 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292401 02706474 |
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