Association of PTPN22 (rs2476601) and STAT4 (rs7574865) polymorphisms with Rheumatoid Arthritis in the Western Algerian population
| العنوان: | Association of PTPN22 (rs2476601) and STAT4 (rs7574865) polymorphisms with Rheumatoid Arthritis in the Western Algerian population |
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| المؤلفون: | Fodil, M., Benzaoui, A., Zemani-Fodil, F., Aberkane, M., Boughrara, W., Saidi-Mehtar, N., Petit-Teixeira, Elisabeth, Boudjema, A. |
| المساهمون: | Laboratoire de recherche européen pour la polyarthrite rhumatoïde (GenHotel), Université d'Évry-Val-d'Essonne (UEVE), Université des sciences et de la Technologie d'Oran Mohamed Boudiaf [Oran] (USTO MB), Service de Rhumatologie [CHU d'Oran], Laboratoire de Génétique Moléculaire et Cellulaire, HAL, Univ Évry |
| المصدر: | Acta Reumatológica Portuguesa, Vol 2015, Iss 1, Pp 56-62 (2015) Acta Reumatologica Portuguesa Acta Reumatologica Portuguesa, 2015, 40 (1), pp.56--62 Acta Reumatologica Portuguesa, Sociedade Portuguesa de Reumatologia 2015, 40 (1), pp.56--62 |
| بيانات النشر: | Sociedade Portuguesa de Reumatologia, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, rheumatoid arthritis, lcsh:Immunologic diseases. Allergy, lcsh:Internal medicine, Arthritis, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Middle Aged, STAT4 Transcription Factor, PTPN22, Non-Receptor Type 22, Genetic, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Rheumatoid, Algeria, Humans, Algerians, Female, Protein Tyrosine Phosphatase, Polymorphism, lcsh:RC31-1245, lcsh:RC581-607 |
| الوصف: | International audience; AIM: The aim of the present study was to replicate the association of five risk gene polymorphisms (PTPN22-rs2476601, STAT4-rs7574865, 6q23-rs6927172, IRF5-rs2004640 and TRAF1/C5-rs10818488) with RA in a specific population of the Western Algeria. MATERIAL AND METHODS: The study group comprised 110 patients with RA and 197 ethnically matched healthy control subjects. All polymorphisms were genotyped using predesigned TaqMan® assays. Allele and genotype frequencies in patients and control subjects were compared by chi-square test and odds ratios with 95% confidence intervals. Correction for multiple testing was carried out using the Bonferroni adjustment. RESULTS: Statistically significant associations with RA were detected. The strongest signal was obtained for PTPN22-rs2476601 with an allelic Pvalue 3.32 x 10(-11) (OR = 9.83, 95% CI [4.28 - 22.56]). A second significant association was obtained with STAT4-rs7574865 (allelic Pvalue = 4 x 10(-3); OR = 1.75, 95% CI [1.16 - 2.63]). The third SNP, 6q23-rs6927172, showed a significant result of association with RA, but missed our criteria for significance at allelic level after Bonferroni's correction (allelic Pvalue = 0.027; OR = 0.64, 95% CI [0.42 - 0.97]). Finally, IRF5-rs2004640 and TRAF1/C5-rs10818488 showed a significant association only at genotypic level (Pvalues: 3 x 10(-4) and 2.9 x 10(-3) respectively) but did not reach statistical significance when comparing allele frequencies (Pvalues: 0.96 and 0.21 respectively). CONCLUSIONS: From this initial study, we can conclude that PTPN22-rs2476601 and STAT4-rs7574865 polymorphisms are clearly associated with the risk of RA in the Western Algerian population. |
| اللغة: | English |
| تدمد: | 0303-464X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dfbf0a12fc8d830322600a22996bda14Test http://www.actareumatologica.com/files/article/1043_association_of_ptpn22_rs2476601_and_stat4_rs7574865_polymorphisms_with_rheumatoid_arthritis_in_the_western_algerian_population_file.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..dfbf0a12fc8d830322600a22996bda14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0303464X |
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