دورية أكاديمية

Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population

التفاصيل البيبلوغرافية
العنوان: Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population
المؤلفون: Maha S. Al-Shammari, Rhaya Al-Ali, Nader Al-Balawi, Mansour S. Al-Enazi, Ali A. Al-Muraikhi, Fadi N. Busaleh, Ali S. Al-Sahwan, Abdulmohsen Al-Elq, Awatif N. Al-Nafaie, Jesu Francis Borgio, Sayed AbdulAzeez, Amein Al-Ali, Sadananda Acharya
المصدر: Genetics and Molecular Biology, Vol 40, Iss 3, Pp 586-590 (2017)
بيانات النشر: Sociedade Brasileira de Genética, 2017.
سنة النشر: 2017
المجموعة: LCC:Genetics
مصطلحات موضوعية: T2D, CVD, KCNQ1, genetic association, Saudi population, Genetics, QH426-470
الوصف: Abstract Genome-wide association studies have identified several loci associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes (T2D). Polymorphisms within the KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) gene are consistently associated with T2D in a number of populations. The current study was undertaken to evaluate the association of 3 polymorphisms of KCNQ1 (rs2237892, rs151290 and rs2237895) with T2D and/or CVD. Patients diagnosed with either T2D (320 patients), CVD (250 patients) or both (60 patients) and 516 healthy controls were genotyped by TaqMan assay run on a real time PCR thermocycler. A statistically significant association was found for SNPs rs151290 (OR = 1.76; 95%CI = 1.02-3.05; p = 0.0435) and rs2237895 (OR = 2.49; 95%CI = 1.72-3.61; p < 0.0001) with CVD. SNP rs151290 (OR = 7.43; 95%CI = 1.00-55.22; p = 0.0499) showed a strong association in patients with both T2D and CVD. None of the SNPs showed any significant association with T2D. Haploview analysis showed that the ACC (rs151290, rs2237892 and rs2237895) haplotype is the most significant risk allele combination for CVD, while CCA is the most significant risk haplotype for co-morbidity with T2D. KCNQ1 polymorphism at SNPs rs151290 and rs2237895 is strongly associated with CVD in this population, but presented no association with T2D.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1678-4685
العلاقة: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400586&lng=en&tlng=enTest; https://doaj.org/toc/1678-4685Test
DOI: 10.1590/1678-4685-gmb-2017-0005
الوصول الحر: https://doaj.org/article/73a9fe912f344490a06bbed236ec3249Test
رقم الانضمام: edsdoj.73a9fe912f344490a06bbed236ec3249
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16784685
DOI:10.1590/1678-4685-gmb-2017-0005