دورية أكاديمية
Association Study of Serotonin Transporter Gene Polymorphisms with Obstructive Sleep Apnea Syndrome in Chinese Han Population
| العنوان: | Association Study of Serotonin Transporter Gene Polymorphisms with Obstructive Sleep Apnea Syndrome in Chinese Han Population |
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| المؤلفون: | Yue, Weihua, Liu, Huiguo, Zhang, Jishui, Zhang, Xianghui, Wang, Xiaoping, Liu, Tieqiao, Liu, Pozi, Hao, Wei |
| المساهمون: | Hao, W (reprint author), Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China., Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China., Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China., Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430074, Peoples R China., Capital Univ Med Sci, Beijing Childrens Hosp, Beijing, Peoples R China., Tsinghua Univ, Affiliated Hosp 2, Beijing 100084, Peoples R China., Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | sleep |
| سنة النشر: | 2008 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Obstructive sleep apnea syndrome (OSAS), serotonin transporter (5-HTT), association study, EXTRACELLULAR SEROTONIN, AFFECTIVE-DISORDERS, HYPOPNEA SYNDROME, SUSCEPTIBILITY, SYMPTOMATOLOGY, EPIDEMIOLOGY, AGGREGATION, INHERITANCE, PERFORMANCE, SYMPTOMS |
| الوصف: | Background: Since the serotonin (5-HT) is associated with circadian rhythm and breathing regulation, the serotonin transporter (5-HTT), which plays an important role in serotoninergic transmission, might be a strong candidate gene in the pathogenesis of obstructive sleep apnea syndrome (OSAS). Objective: To investigate the association of 5-HTT gene polymorphisms with OSAS and clinical characteristics. Methods: We genotyped the 5-HTT gene linked polymorphic region (5-HTTLPR) and a variable number of tandem repeats at intron 2 (STin2.VNTR) in 254 OSAS patients and 338 healthy controls in Chinese Han population. Results: In total sample, the 10-repeat allele of STin2.VNTR was significantly associated with OSAS (P = 0.007, OR = 1.72, 95% Cl = 1.15-2.58), but no association was found in 5-HTTLPR. In male subjects, both polymorphisms showed significant association with OSAS (Allele L: P 0.005, OR = 1.44, 95% Cl = 1.11 to 1.87; Allele 10: P = 0.002, OR 1.94, 95% Cl = 1.26 to 3.00). Two haplotypes, S-12 and L-10, constructed by the above polymorphisms also revealed significant associations with OSAS (global P-values were 0.020 for total sample and 0.0006 for male subjects, respectively). Male patients carrying the haplotype S-12 showed a significantly lower apnea / hypopnea index (AHI), depressive factor, plasma 5-HT level and 5-hydroxyindolacetic acid (5-HIAA) levels, but higher episodic memory, when compared with non-S-12 carriers (P < 0.05). However, no significant differences were found in excessive daytime sleepiness or other psychological function across haplotype carriers (P > 0.05). Conclusions: These findings support that 5-HTT gene may be involved in susceptibility to OSAS, especially with sex-dependent effect. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260550100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Clinical Neurology ; Neurosciences ; SCI(E) ; 25 ... |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0161-8105 |
| العلاقة: | SLEEP.2008,31,(11),1535-1541.; 957311; http://hdl.handle.net/20.500.11897/397156Test; WOS:000260550100012 |
| الإتاحة: | https://doi.org/20.500.11897/397156Test https://hdl.handle.net/20.500.11897/397156Test |
| رقم الانضمام: | edsbas.F46511DC |
| قاعدة البيانات: | BASE |
| تدمد: | 01618105 |
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