المؤلفون: Valentina Angerilli, Matteo Fassan, Paola Parente, Irene Gullo, Michela Campora, Chiara Rossi, Maria Luisa Sacramento, Gianmaria Pennelli, Alessandro Vanoli, Federica Grillo, Luca Mastracci

المصدر: Pathologica. 115:57-70

مصطلحات موضوعية: PD-L1, immunohistochemistry, immunotherapy, esophageal squamous cell carcinoma, gastroesophageal adenocarcinoma, Pathology and Forensic Medicine

الوصف: PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker, due to changing cut-off values and scoring systems, interobserver and interlaboratory variability.This practical illustrated review discusses the range of staining patterns of PD-L1 and the potential pitfalls and challenges that can be encountered when evaluating PD-L1, focusing on gastric and gastroesophageal adenocarcinoma (G/GEA) and esophageal squamous cell carcinoma (ESCC).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe41b80fc31973892bcd6de78bbd24a8Test
https://doi.org/10.32074/1591-951x-836Test

المؤلفون: Federica Grillo, Rita Alaggio, Paola De Angelis, Angelica Dirodi, Paola Parente, Chiara Rossi, Paola Francalanci, Alessandro Vanoli, Luca Mastracci, Giovanni Arpa, Mario Pastore, Irene Gullo, Matteo Fassan

المصدر: Pathologica. 114:3-11

مصطلحات موضوعية: Adult, Pediatrics, medicine.medical_specialty, VEO-IBD, IBD, Context (language use), primary immunodeficiency, Inflammatory bowel disease, Crohn’s Disease, monogenic diseases, pediatric diseases, ulcerative colitis, Pathology and Forensic Medicine, Diagnosis, Differential, Multidisciplinary approach, Diagnosis, medicine, Humans, Age of Onset, Colitis, Child, Crohn's disease, business.industry, Phenotype, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, digestive system diseases, Differential, Primary immunodeficiency, Differential diagnosis, business

الوصف: Very early onset inflammatory bowel disease (VEO-IBD) represents approximately 25% of cases of IBD-like colitis occurring during childhood and, by definition, it is characterized by an onset prior to 6 years of age. This subgroup of patients presents significant differences from IBD occurring in older children and in adults, including a more severe clinical course, a reduced responsiveness to conventional IBD therapy, and a greater proportion of cases featuring an underlying monogenic disorder. Histological findings from gastro-intestinal (GI) biopsies are characterized by an IBD-like, apoptotic or enterocolitis-like pattern, complicating the differential diagnosis with other pediatric diseases involving GI tract. Moreover, individuals with monogenic disorders may develop significant comorbidities, such as primary immunodeficiency (PID), impacting treatment options. Without an appropriate diagnosis, the clinical course of VEO-IBD has greater potential for escalated treatment regimens involving extensive surgery, more intensive medical therapies and, even more important, inadequate recognition of underlying monogenic defect that may lead to inappropriate (sometimes fatal) therapy. For these reasons, an adequate context leading to an appropriate diagnosis is imperative, calling for a close collaboration between pediatricians, pathologists, geneticists, and immunologists.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da75ec7e1a8434975fd33d8dc4946d9Test
https://doi.org/10.32074/1591-951x-336Test

المؤلفون: Samantha Sarcognato, Diana Sacchi, Matteo Fassan, Luca Fabris, Massimiliano Cadamuro, Giacomo Zanus, Ivana Cataldo, Paola Capelli, Francesca Baciorri, Matilde Cacciatore, Maria Guido

المصدر: Pathologica

مصطلحات موضوعية: subtypes, fungi, information science, Review, Pathology and Forensic Medicine, neoplasia, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, malignant, parasitic diseases, biliary, cholangiocarcinoma, cardiovascular system, Humans, cardiovascular diseases

الوصف: Summary Liver cancer represents the third leading cause of cancer-related death worldwide. Cholangiocarcinoma (CCA) is the second most common type of liver cancer after hepatocellular carcinoma, accounting for 10-15% of all primary liver malignancies. Both the incidence and mortality of CCA have been steadily increasing during the last decade. Moreover, most CCAs are diagnosed at an advanced stage, when therapeutic options are very limited. CCA may arise from any tract of the biliary system and it is classified into intrahepatic, perihilar, and distal CCA, according to the anatomical site of origin. This topographical classification also reflects distinct genetic and histological features, risk factors, and clinical outcomes. This review focuses on histopathology of CCA, its differential diagnoses, and its diagnostic pitfalls.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33a10963c7291237dce9c47e88a6ad5Test
https://doi.org/10.32074/1591-951x-252Test

المؤلفون: Alessandro Vanoli, Elettra Unti, Luca Mastracci, Alessandro D'Amuri, Paola Parente, Serena Battista, Matteo Fassan

المصدر: Pathologica

مصطلحات موضوعية: medicine.medical_specialty, 2019-20 coronavirus outbreak, Gastrointestinal tract, Coronavirus disease 2019 (COVID-19), business.industry, General surgery, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Gastroenterology, Gastrointestinal Tract, Humans, Societies, Medical, Pathologists, Pathology and Forensic Medicine, Editorial, Medical, medicine, Societies, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a79d04d29192d2625ee3f1eba5eb2fTest
https://doi.org/10.32074/1591-951x-160Test