دورية أكاديمية
Effect of Methanolic Extract of Cassia Fistula to Prevent Erythrocyte Sickling
| العنوان: | Effect of Methanolic Extract of Cassia Fistula to Prevent Erythrocyte Sickling |
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| المؤلفون: | Nazanin Heidari, Parisa Rezaei Mofrad, Mohammad Ali Jalali Far, Mohammad Taha Jalali |
| المصدر: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 31, Iss 1, Pp 6278-6285 (2023) |
| بيانات النشر: | Shahid Sadoughi University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | sickle cell trait, methanol, cassia, therapeutics., Medicine (General), R5-920 |
| الوصف: | Introduction: Due to the pathophysiology of Sickle cell disease (SCD), several treatment strategies have been reviewed so far. One of the strategies is anti-sickling factors. This study was performed to determine the effect of methanolic extract of Cassia Fistula fruit on sickle cell sickling in vitro. Methods: In this laboratory study, 25 people with sickle cell trait (SCT) ranging in age from 3 to 27 years, and 5 healthy people (as a control) participated. Cassia Fistula was introduced by Dr. Mohammad Taha Jalali to be used in this project. Methanolic extract of Cassia Fistula fruit was obtained by maceration using vacuum distillation (rotary evaporator). Samples with sickle cell trait were examined for sickle cell before and after extract interference, in hypoxic condition. Data analysis was performed by SPSS software version16. Results: In this study, 64% of the participants were male and 36% were female. Sickling rates in 1:50, 1: 100 and 1: 200 dilutions were 24%, 37.8% and 46.1%, respectively. According to Wilcoxon Test, the rate of sickling in 1: 2 to 1: 100 dilutions was significantly reduced, relative to pre-interference conditions (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 2228-5741 2228-5733 75048353 |
| العلاقة: | http://jssu.ssu.ac.ir/article-1-5411-en.htmlTest; https://doaj.org/toc/2228-5741Test; https://doaj.org/toc/2228-5733Test |
| الوصول الحر: | https://doaj.org/article/75048353368747a69714e82aa5c6b906Test |
| رقم الانضمام: | edsdoj.75048353368747a69714e82aa5c6b906 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22285741 22285733 75048353 |
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