دورية أكاديمية
PHYSIOPATHOLOGY OF DIABETIC KIDNEY DISEASE
| العنوان: | PHYSIOPATHOLOGY OF DIABETIC KIDNEY DISEASE |
|---|---|
| المؤلفون: | Fabiana Vázquez |
| المصدر: | Revista de la Sociedad Argentina de Diabetes, Vol 51, Iss 3, Pp 69-76 (2018) |
| بيانات النشر: | Sello Editorial Lugones, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Nutritional diseases. Deficiency diseases LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | enfermedad renal por diabetes, hiperglucemia, podocitos, sglt-1, sglt-2, “feedback túbulo-glomerular”, aumento de la presión intraglomerular, Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Kidney disease caused by diabetes is a microvascular compli- cation in which hemodynamic, metabolic changes, oxidative stress and inflammation increase occur in the kidneys. This determines an increase of the mesangial extracellular matrix, basement membrane thickness, loss of podocyte foot and tubu- lar cells disruption with fibrosis and proteinuria. The increase of receptors SGLT-1 and SGLT-2 expression, with the resulting and marked reduction of Na+ offer to the macula densa is wrongly construed as a reduction of plasmatic volume by the yuxta-glo- merular complex through the “tubuloglomerular feedback”, ge- nerating vasodilation of the afferent arterioles and the resulting increase in intraglomerular pressure. This changes the classical glomerular concept, interpreting that there may be an initial le- sion at the tubular level. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Spanish; Castilian |
| تدمد: | 0325-5247 2346-9420 |
| العلاقة: | https://www.revistasad.com/index.php/diabetes/article/view/101Test; https://doaj.org/toc/0325-5247Test; https://doaj.org/toc/2346-9420Test |
| DOI: | 10.47196/diab.v51i3.101 |
| الوصول الحر: | https://doaj.org/article/e2d2e6e7ddfd47c9bb191d645cf488afTest |
| رقم الانضمام: | edsdoj.2d2e6e7ddfd47c9bb191d645cf488af |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 03255247 23469420 |
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| DOI: | 10.47196/diab.v51i3.101 |